血清肿瘤标志物在肺结核诊断中的预测作用
Predictive Role of Serum Tumor Markers in Diagnosis of Pulmonary Tuberculosis.
作者信息
Ma Jingjing, Xia Dan, Hu Jing, Fu Rui, Xu Lijun, Zhang Ying, Zhang Mengying, Li Benhe, Yang Jianghua, Wen Yufeng
机构信息
Dept. of Preventive Medicine, School of Public Health, Wannan Medical College, Wuhu City, China.
Dept. of Infectious Diseases, Yijishan Hospital, Wuhu City, China.
出版信息
Iran J Public Health. 2016 Apr;45(4):435-40.
BACKGROUND
The diagnosis of pulmonary tuberculosis (PTB) is complicated and time-consuming currently. There was association of PTB with serum tumor markers. In this study we aimed to evaluate the predictive role of serum CA125, CA199 and CEA as diagnostic tools for PTB.
METHODS
This study was designed as a case-control study with 565 subjects who visited the Yijishan Hospital from Jun to Dec in 2014.This case-control study matched as for age and sex with 113 cases and 452 controls. Serum CA125, CA199 and CEA levels were detected by electrochemiluminescence instrument. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve was performed to evaluate the diagnostic value on PTB.
RESULTS
Serum levels of CA125, CA199 and CEA in PTB patients were significantly higher than those in control group (P<0.001). There was no significantly different of three tumor markers between initial treatment group and retreatment group. The logistic regression analysis showed that CA125 was an impact factor to PTB. The ROC analysis revealed that AUC of CA125 was 0.966 (95%CI: 0.951-0.981), the sensitivity, specificity in serum and cut-off were 95.6%, 85.0% and 10.30 U/ml, respectively.
CONCLUSION
The serum CA125 has potential good diagnostic performance for PTB.
背景
目前肺结核（PTB）的诊断复杂且耗时。PTB与血清肿瘤标志物有关联。在本研究中，我们旨在评估血清CA125、CA199和CEA作为PTB诊断工具的预测作用。
方法
本研究设计为病例对照研究，纳入了2014年6月至12月期间就诊于弋矶山医院的565名受试者。该病例对照研究在年龄和性别上进行匹配，包括113例病例和452例对照。采用电化学发光仪检测血清CA125、CA199和CEA水平。通过绘制受试者工作特征（ROC）曲线并计算曲线下面积（AUC）来评估其对PTB的诊断价值。
结果
PTB患者血清CA125、CA199和CEA水平显著高于对照组（P<0.001）。初治组和复治组的三种肿瘤标志物水平无显著差异。逻辑回归分析显示CA125是PTB的一个影响因素。ROC分析显示，CA125的AUC为0.966（95%CI：0.951 - 0.981），血清中的敏感性、特异性和临界值分别为95.6%、85.0%和10.30 U/ml。
结论
血清CA125对PTB具有潜在的良好诊断性能。
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