Microbiome. 2016 Jun 3;4(1):24. doi: 10.1186/s40168-016-0168-z.
The Metagenomics and Metadesign of the Subways and Urban Biomes (MetaSUB) International Consortium is a novel, interdisciplinary initiative comprised of experts across many fields, including genomics, data analysis, engineering, public health, and architecture. The ultimate goal of the MetaSUB Consortium is to improve city utilization and planning through the detection, measurement, and design of metagenomics within urban environments. Although continual measures occur for temperature, air pressure, weather, and human activity, including longitudinal, cross-kingdom ecosystem dynamics can alter and improve the design of cities. The MetaSUB Consortium is aiding these efforts by developing and testing metagenomic methods and standards, including optimized methods for sample collection, DNA/RNA isolation, taxa characterization, and data visualization. The data produced by the consortium can aid city planners, public health officials, and architectural designers. In addition, the study will continue to lead to the discovery of new species, global maps of antimicrobial resistance (AMR) markers, and novel biosynthetic gene clusters (BGCs). Finally, we note that engineered metagenomic ecosystems can help enable more responsive, safer, and quantified cities.
地铁和城市生物群元基因组学和元设计（MetaSUB）国际联合会是一个新颖的跨学科倡议，由包括基因组学、数据分析、工程、公共卫生和建筑等多个领域的专家组成。MetaSUB 联合会的最终目标是通过检测、测量和设计城市环境中的元基因组学，来改善城市的利用和规划。尽管一直在对温度、气压、天气和人类活动进行持续测量，但包括纵向、跨生物界生态系统动态在内的因素会改变和改善城市的设计。MetaSUB 联合会正在通过开发和测试元基因组学方法和标准来协助这些工作，包括优化的样本采集、DNA/RNA 分离、分类特征和数据可视化方法。该联合会产生的数据可以帮助城市规划者、公共卫生官员和建筑设计师。此外，该研究将继续发现新的物种、全球抗生素耐药性（AMR）标志物图谱和新型生物合成基因簇（BGC）。最后，我们注意到，工程化的元基因组学生态系统可以帮助实现更具响应性、更安全和更量化的城市。
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