基质内角膜色素沉着中微粉化矿物色素的耐受性：一项组织病理学和免疫病理学实验研究。
Tolerance of Micronized Mineral Pigments for Intrastromal Keratopigmentation: A Histopathology and Immunopathology Experimental Study.
作者信息
Amesty Maria A, Rodriguez Alejandra E, Hernández Enrique, De Miguel Maria P, Alio Jorge L
机构信息
*Ocular Adnexal Service, Moorfields Eye Hospital, London, UK; †Research & Development Department, VISSUM, Alicante, Spain; ‡Tumor Immunology Department and Innate Immunity Group, IdiPAZ, La Paz Hospital Research Institute, Madrid, Spain; §Cell Engineering Laboratory, IdiPAZ, La Paz Hospital Research Institute, Madrid, Spain; and ¶Department of Ophthalmology, Miguel Hernández University, and Department of Cornea and Refractive Surgery, VISSUM, Alicante, Spain.
出版信息
Cornea. 2016 Sep;35(9):1199-205. doi: 10.1097/ICO.0000000000000900.
PURPOSE
To study the tolerance and biocompatibility of mineral pigments for corneal pigmentation histopathologically and immunologically in an experimental animal model.
METHODS
Manual intralamellar keratopigmentation was performed in 28 New Zealand white rabbits using micronized mineral pigments. Histopathological examination was performed 3 months after the surgery to determine the level of pigment diffusion, the level of inflammation, and the presence/absence of neovascularization. An immunological analysis was also performed.
RESULTS
No pigment diffusion or changes in color, inflammation, or neovascularization were detected in the treated eyes. Histopathological examination corroborated clinical results regarding inflammation. Pigmented corneas showed a good cosmetic appearance without signs of ocular toxicity. From the immunological perspective, the pigments do not generate an inflammatory response in the rabbit cornea or in vitro.
CONCLUSIONS
Micronized mineral pigments could be a valid alternative treatment for corneal pigmentation. Manual intralamellar keratopigmentation technique presented good cosmetic appearance without adverse effects in the treated eyes.
目的
在实验动物模型中，从组织病理学和免疫学角度研究用于角膜色素沉着的矿物颜料的耐受性和生物相容性。
方法
使用微粉化矿物颜料对28只新西兰白兔进行手动板层角膜色素沉着。术后3个月进行组织病理学检查，以确定色素扩散程度、炎症程度以及是否存在新生血管。还进行了免疫学分析。
结果
在治疗的眼睛中未检测到色素扩散或颜色、炎症或新生血管的变化。组织病理学检查证实了关于炎症的临床结果。色素沉着的角膜外观良好，没有眼毒性迹象。从免疫学角度来看，这些颜料在兔角膜或体外均未产生炎症反应。
结论
微粉化矿物颜料可能是角膜色素沉着的一种有效替代治疗方法。手动板层角膜色素沉着技术在治疗的眼睛中呈现出良好的外观，且无不良反应。
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