使用VOCAL对子宫内膜异位囊肿内容物进行平均灰度值评估的两种不同方法的可重复性。
Reproducibility of two different methods for performing mean gray value evaluation of cyst content in endometriomas using VOCAL.
作者信息
Guerriero Stefano, Alcazar Juan Luis, Pilloni Monica, Ajossa Silvia, Olartecoechea Begoña, Sedda Federica, Piras Alba, Melis Gian Benedetto, Saba Luca
机构信息
Department of Obstetrics and Gynaecology, Ospedale San Giovanni di Dio, University of Cagliari, Via Ospedale 46, 09124, Cagliari, Italy.
Clinica Universitaria de Navarra, University of Navarra, Pamplona, Spain.
出版信息
J Med Ultrason (2001). 2014 Jul;41(3):325-32. doi: 10.1007/s10396-013-0514-8. Epub 2013 Dec 31.
OBJECTIVE
To compare two different methods (manual sampling of the entire cyst and semi-automated spherical sampling from the central part of the cyst) for calculating the mean gray value (MGV) from the cystic content in endometriomas using virtual organ computer-aided analysis (VOCAL).
METHODS
Forty-one volumes from histologically confirmed endometriomas were retrieved from our database and the volumes were analyzed to compare the MGVs obtained via the two modalities. In addition, to evaluate the reproducibility in a sample of 20 volumes, two different observers calculated the MGV from cyst content using VOCAL software. For each method, each examiner analyzed the volumes twice, 3 weeks apart, for assessment of intra-observer agreement. First, manual sampling of the internal contour of all the cysts was performed, and 1 week later semi-automated 2-cm sphere sampling from the central part of the cyst was carried out. In addition, the observers recorded the time spent performing each analysis. Inter- and intra-observer reproducibility was evaluated for each method using intra-class correlation coefficients (ICC).
RESULTS
There was no difference in the mean MGV between manual sampling (22.211 ± 7.541) and the semi-automated modality of sampling (23.840 ± 8.621, p = 0.439). The correlation between manual and semi-automated sampling measurement was high (r = 0.92). According to the ICCs, there was no significant difference in interobserver reliability between manual sampling (0.931; 95 % CI, 0.824-0.973) and the semi-automated modality of sampling (0.924; 95 % CI, 0.809-0.970). Intra-observer reproducibility for both examiners was good (ICC > 0.94). Semi-automated measurements were obtained faster than those obtained by manual evaluation (p = 0.0001 for observer 1 and p = 0.083 for observer 2).
CONCLUSIONS
Both methods seem to be reliable, but the semi-automated method using the sphere should be preferred because it is a less time-consuming procedure.
目的
使用虚拟器官计算机辅助分析（VOCAL）比较两种不同方法（对整个囊肿进行手动采样和从囊肿中央部分进行半自动球形采样）计算子宫内膜异位囊肿囊内容物的平均灰度值（MGV）。
方法
从我们的数据库中检索出41例经组织学证实的子宫内膜异位囊肿的容积数据，并对这些容积数据进行分析，以比较通过两种方式获得的MGV。此外，为了评估20例容积样本的可重复性，两名不同的观察者使用VOCAL软件计算囊肿内容物的MGV。对于每种方法，每位检查者对这些容积数据进行两次分析，间隔3周，以评估观察者内一致性。首先，对所有囊肿的内部轮廓进行手动采样，1周后从囊肿中央部分进行半自动2厘米球体采样。此外，观察者记录每次分析所花费的时间。使用组内相关系数（ICC）评估每种方法的观察者间和观察者内可重复性。
结果
手动采样（22.211±7.541）和半自动采样方式（23.840±8.621，p = 0.439）之间的平均MGV没有差异。手动采样和半自动采样测量之间的相关性很高（r = 0.92）。根据ICC，手动采样（0.931；95%CI，0.824 - 0.973）和半自动采样方式（0.924；95%CI，0.809 - 0.970）之间的观察者间可靠性没有显著差异。两位检查者的观察者内可重复性都很好（ICC > 0.94）。半自动测量比手动评估获得结果的速度更快（观察者1为p = 0.0001，观察者2为p = 0.083）。
结论
两种方法似乎都可靠，但使用球体的半自动方法更应被首选，因为它是一种耗时较少的程序。
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