Miller H C, Jekel J F
Department of Pediatrics, University of Kansas Medical Center, College of Health Sciences, Kansas City 66103.
Yale J Biol Med. 1989 Jan-Feb;62(1):1-12.
Fetal growth retardation was diagnosed in 137 (7.8 percent) of 1,757 white full-term infants who had crown-heel lengths below the fifth percentiles for their gestational ages. The incidence of short infants was 121 (11.1 percent) among 1,093 mothers with high-risk pregnancies compared to 16 (2.4 percent) in 664 low-risk mothers (p less than 0.0001). There were four high-risk categories: spontaneous premature rupture of membranes (PROM), fetal conditions, complications of pregnancy, and adverse maternal practices. The incidence of short infants was significantly higher in each of the four high-risk categories than in the low-risk group. There were three other conditions that were present in all pregnancies that were associated with the frequency of short infants: maternal height, socioeconomic status of head of household, and sex of infant. A short maternal height (under 157.7 cm = 62 inches) was significantly associated with an increase in short infants among mothers who smoked cigarettes at any level during pregnancy and among mothers with PROM in combination with other risks, but not in the group of 664 low-risk mothers. Significantly more short girls than short boys were born to mothers who smoked ten or more cigarettes a day throughout pregnancy or who had multiple adverse maternal practices, but no statistically significant differences were noted among mothers who smoked fewer than ten cigarettes per day, among those with PROM as the only risk factor, or among those with medical or obstetrical complications. Moreover, those mothers who were in socioeconomic groups III and IV and had other risk factors had a significantly higher incidence of short infants than did similar mothers in socioeconomic groups I and II.
在1757名白人足月婴儿中,有137名(7.8%)被诊断为胎儿生长受限,这些婴儿的顶臀长度低于其孕周的第五百分位数。在1093名高危妊娠母亲中,身材矮小婴儿的发生率为121名(11.1%),而在664名低危母亲中为16名(2.4%)(p<0.0001)。有四个高危类别:胎膜早破(PROM)、胎儿状况、妊娠并发症和不良母体行为。在四个高危类别中,身材矮小婴儿的发生率均显著高于低危组。在所有妊娠中还存在其他三种与身材矮小婴儿发生率相关的情况:母亲身高、户主的社会经济地位和婴儿性别。母亲身高矮小(低于157.7厘米=62英寸)与孕期任何水平吸烟的母亲以及伴有其他风险因素的胎膜早破母亲中身材矮小婴儿数量的增加显著相关,但在664名低危母亲组中并非如此。在整个孕期每天吸烟10支或更多支的母亲或有多种不良母体行为的母亲所生的女孩中,身材矮小的明显多于男孩,但在每天吸烟少于10支的母亲、以胎膜早破为唯一风险因素的母亲或有医疗或产科并发症的母亲中,未发现有统计学意义的差异。此外,处于社会经济群体III和IV且有其他风险因素的母亲所生身材矮小婴儿的发生率明显高于社会经济群体I和II中的类似母亲。