LAP：自身免疫的保护者。
LAP: the protector against autoimmunity.
机构信息
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
出版信息
Cell Res. 2016 Aug;26(8):865-6. doi: 10.1038/cr.2016.70. Epub 2016 Jun 14.
Abstract
The autophagy-related process LC3-Associated Phagocytosis, or LAP, is known to control the degradation of engulfed cells and microorganisms. Now Martinez et al. discover that LAP controls immune responses to dying cells and its inhibition leads to development of Systemic Lupus Erythematosus-like disease.
摘要
自噬相关过程 LC3 相关噬作用（LC3-Associated Phagocytosis，或 LAP），已知可控制被吞噬细胞和微生物的降解。现在，Martinez 等人发现 LAP 控制对死亡细胞的免疫反应，其抑制导致红斑狼疮样疾病的发展。
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