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无机纳米材料作为药物递送载体

Inorganic Nanomaterials as Carriers for Drug Delivery.

作者信息

Chen Shizhu, Hao Xiaohong, Liang Xingjie, Zhang Qun, Zhang Cuimiao, Zhou Guoqiang, Shen Shigang, Jia Guang, Zhang Jinchao

出版信息

J Biomed Nanotechnol. 2016 Jan;12(1):1-27. doi: 10.1166/jbn.2016.2122.

Abstract

For safe and effective therapy, drugs must be delivered efficiently and with minimal systemic side effects. Nanostructured drug carriers enable the delivery of small-molecule drugs as well as nucleic acids and proteins. Inorganic nanomaterials are ideal for drug delivery platforms due to their unique physicochemical properties, such as facile preparation, good storage stability and biocompatibility. Many inorganic nanostructure-based drug delivery platforms have been prepared. Although there are still many obstacles to overcome, significant advances have been made in recent years. This review focuses on the status and development of inorganic nanostructures, including silica, quantum dots, gold, carbon-based and magnetic iron oxide-based nanostructures, as carriers for chemical and biological drugs. We specifically highlight the extensive use of these inorganic drug carriers for cancer therapy. Finally, we discuss the most important areas in the field that urgently require further study.

摘要

为实现安全有效的治疗,药物必须高效递送且全身副作用最小。纳米结构药物载体能够递送小分子药物以及核酸和蛋白质。无机纳米材料因其独特的物理化学性质,如制备简便、储存稳定性好和生物相容性佳,是理想的药物递送平台。许多基于无机纳米结构的药物递送平台已被制备出来。尽管仍有许多障碍有待克服,但近年来已取得了显著进展。本综述聚焦于无机纳米结构的现状与发展,包括二氧化硅、量子点、金、碳基和磁性氧化铁基纳米结构,作为化学和生物药物的载体。我们特别强调这些无机药物载体在癌症治疗中的广泛应用。最后,我们讨论了该领域迫切需要进一步研究的最重要领域。

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