挥发性麻醉药免疫效应的机制：综述
Mechanisms of the Immunological Effects of Volatile Anesthetics: A Review.
作者信息
Yuki Koichi, Eckenhoff Roderic G
机构信息
From the *Department of Anesthesiology, Perioperative and Pain Medicine, Cardiac Anesthesia Division, Boston Children's Hospital, Boston, Massachusetts; †Department of Anaesthesia, Harvard Medical School, Boston, Massachusetts; and ‡Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
出版信息
Anesth Analg. 2016 Aug;123(2):326-35. doi: 10.1213/ANE.0000000000001403.
Volatile anesthetics (VAs) have been in clinical use for a very long time. Their mechanism of action is yet to be fully delineated, but multiple ion channels have been reported as targets for VAs (canonical VA targets). It is increasingly recognized that VAs also manifest effects outside the central nervous system, including on immune cells. However, the literature related to how VAs affect the behavior of immune cells is very limited, but it is of interest that some canonical VA targets are reportedly expressed in immune cells. Here, we review the current literature and describe canonical VA targets expressed in leukocytes and their known roles. In addition, we introduce adhesion molecules called β2 integrins as noncanonical VA targets in leukocytes. Finally, we propose a model for how VAs affect the function of neutrophils, macrophages, and natural killer cells via concerted effects on multiple targets as examples.
挥发性麻醉剂（VAs）已在临床使用很长时间。其作用机制尚未完全阐明，但已有多种离子通道被报道为VAs的靶点（经典VA靶点）。人们越来越认识到，VAs在中枢神经系统之外也表现出作用，包括对免疫细胞的作用。然而，关于VAs如何影响免疫细胞行为的文献非常有限，但有趣的是，据报道一些经典VA靶点在免疫细胞中表达。在此，我们综述当前文献，并描述在白细胞中表达的经典VA靶点及其已知作用。此外，我们介绍一种称为β2整合素的黏附分子作为白细胞中的非经典VA靶点。最后，我们以VAs如何通过对多个靶点的协同作用影响中性粒细胞、巨噬细胞和自然杀伤细胞的功能为例，提出一个模型。
Zotero 插件