神经血管P450在脑部疾病中的病理生理学意义。
Pathophysiological implications of neurovascular P450 in brain disorders.
作者信息
Ghosh Chaitali, Hossain Mohammed, Solanki Jesal, Dadas Aaron, Marchi Nicola, Janigro Damir
机构信息
Cerebrovascular Research, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA; Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA; Department of Molecular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
Cerebrovascular Research, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA; Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.
出版信息
Drug Discov Today. 2016 Oct;21(10):1609-1619. doi: 10.1016/j.drudis.2016.06.004. Epub 2016 Jun 14.
Over the past decades, the significance of cytochrome P450 (CYP) enzymes has expanded beyond their role as peripheral drug metabolizers in the liver and gut. CYP enzymes are also functionally active at the neurovascular interface. CYP expression is modulated by disease states, impacting cellular functions, detoxification, and reactivity to toxic stimuli and brain drug biotransformation. Unveiling the physiological and molecular complexity of brain P450 enzymes will improve our understanding of the mechanisms underlying brain drug availability, pharmacological efficacy, and neurotoxic adverse effects from pharmacotherapy targeting brain disorders.
在过去几十年中，细胞色素P450（CYP）酶的重要性已超出其在肝脏和肠道中作为外周药物代谢酶的作用。CYP酶在神经血管界面也具有功能活性。CYP的表达受疾病状态调节，影响细胞功能、解毒作用以及对毒性刺激和脑内药物生物转化的反应性。揭示脑内P450酶的生理和分子复杂性将增进我们对脑内药物可及性、药理疗效以及针对脑部疾病的药物治疗所产生的神经毒性不良反应背后机制的理解。
Zotero 插件