从基因工程菌株阿维链霉菌MHJ1011中获得的两种新型替沃菌素。
Two new tenvermectins from a genetically engineered strain Streptomyces avermitilis MHJ1011.
作者信息
Wan Xu, Zhang Shao-Yong, Zhang Hui, Zhai Jun, Huang Jun, Chen An-Liang, Wang Ji-Dong
机构信息
a Provincial Joint Engineering Laboratory of Biopesticide Preparation , School of Forestry & Biotechnology, Zhejiang Agricultural and Forestry University , Lin'An 311300 , China.
b Department of New Drug Screening , Zhejiang Hisun Pharmaceutical Co., Ltd. , Taizhou 318000 , China.
出版信息
J Asian Nat Prod Res. 2017 Apr;19(4):327-332. doi: 10.1080/10286020.2016.1197911. Epub 2016 Jun 22.
Two new tenvermectins, tenvermectins C (1) and D (2), were isolated from Streptomyces avermitilis MHJ1011. Their structures were determined by extensive spectroscopic analysis and by comparison with a related known compound, tenvermectin A. Compounds 1 and 2 exhibited potent nematocidal and acaricidal activities against Bursaphelenchus xylophilus and Tetranychus cinnabarinus.
从阿维链霉菌MHJ1011中分离出两种新的替沃菌素，即替沃菌素C（1）和D（2）。通过广泛的光谱分析并与相关已知化合物替沃菌素A进行比较确定了它们的结构。化合物1和2对松材线虫和朱砂叶螨表现出强效的杀线虫和杀螨活性。
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