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精准医学时代的乳腺癌研究

[Breast cancer research in the era of precision medicine].

作者信息

Yang H Y, Jiang Y Z, Shao Z M

机构信息

Department of Breast Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

出版信息

Zhonghua Zhong Liu Za Zhi. 2016 Jun 23;38(6):401-3. doi: 10.3760/cma.j.issn.0253-3766.2016.06.001.

Abstract

Precision medicine is an emerging medical strategy that takes into account individual molecular variations of disease to guide accurate prevention and treatment.Tumor molecular markers closely related to aggressive behavior and treatment response will be identified by integrating clinical information and multiple-omics, and will be verified in well-designed clinical trials. Breast cancer is a highly heterogeneous disease. Its treatment based on molecular subtyping has achieved initial success. However, drug resistance and tumor heterogeneity are still major challenges. This review will focus on the recent progress and future prospects of clinical research on breast cancer in the era of precision medicine.

摘要

精准医学是一种新兴的医学策略,它考虑疾病的个体分子变异以指导精确的预防和治疗。通过整合临床信息和多组学技术,将识别与侵袭性行为和治疗反应密切相关的肿瘤分子标志物,并在精心设计的临床试验中进行验证。乳腺癌是一种高度异质性的疾病。基于分子亚型的治疗已取得初步成功。然而,耐药性和肿瘤异质性仍然是主要挑战。本综述将聚焦精准医学时代乳腺癌临床研究的最新进展和未来前景。

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