尼日利亚的埃博拉病毒流行病学与演变
Ebola Virus Epidemiology and Evolution in Nigeria.
作者信息
Folarin Onikepe A, Ehichioya Deborah, Schaffner Stephen F, Winnicki Sarah M, Wohl Shirlee, Eromon Philomena, West Kendra L, Gladden-Young Adrianne, Oyejide Nicholas E, Matranga Christian B, Deme Awa Bineta, James Ayorinde, Tomkins-Tinch Christopher, Onyewurunwa Kenneth, Ladner Jason T, Palacios Gustavo, Nosamiefan Iguosadolo, Andersen Kristian G, Omilabu Sunday, Park Daniel J, Yozwiak Nathan L, Nasidi Abdusallam, Garry Robert F, Tomori Oyewale, Sabeti Pardis C, Happi Christian T
机构信息
Department of Biological Sciences African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State.
Department of Broad Institute of Harvard and MIT Department of FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge.
出版信息
J Infect Dis. 2016 Oct 15;214(suppl 3):S102-S109. doi: 10.1093/infdis/jiw190. Epub 2016 Jul 4.
Containment limited the 2014 Nigerian Ebola virus (EBOV) disease outbreak to 20 reported cases and 8 fatalities. We present here clinical data and contact information for at least 19 case patients, and full-length EBOV genome sequences for 12 of the 20. The detailed contact data permits nearly complete reconstruction of the transmission tree for the outbreak. The EBOV genomic data are consistent with that tree. It confirms that there was a single source for the Nigerian infections, shows that the Nigerian EBOV lineage nests within a lineage previously seen in Liberia but is genetically distinct from it, and supports the conclusion that transmission from Nigeria to elsewhere did not occur.
隔离措施将2014年尼日利亚埃博拉病毒（EBOV）病疫情控制在报告的20例病例和8例死亡。我们在此呈现至少19例病例患者的临床数据和接触信息，以及20例中的12例的全长EBOV基因组序列。详细的接触数据几乎可以完整重建此次疫情的传播树。EBOV基因组数据与该传播树一致。它证实尼日利亚的感染有单一源头，表明尼日利亚EBOV谱系嵌套在先前在利比里亚出现的一个谱系中，但在基因上与之不同，并支持未发生从尼日利亚向其他地方传播的结论。
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