蕈样肉芽肿相关的周围神经病变

Peripheral neuropathy associated with mycosis fungoides.

作者信息

Comola M, Nemni R, Comi G, Corbo M, Taccagni G, Besana C, Canal N

机构信息

Department of Neurology, University of Milan, Italy.

出版信息

J Neurol Neurosurg Psychiatry. 1989 Apr;52(4):536-8. doi: 10.1136/jnnp.52.4.536.

DOI:10.1136/jnnp.52.4.536

PMID:2738598

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1032313/

Abstract

A 56 year old man with acute sensory-motor polyneuropathy associated with mycosis fungoides is described. EMG studies showed diffuse signs of muscle denervation. A skin biopsy specimen showed a lymphocyte infiltration in the dermis, composed of mycosis cells characterised by deep invaginations of the nuclear membrane, and small Pautrier's microabscesses in the epidermis. Sural nerve biopsy revealed endoneurial fibrosis, a decreased number of myelinated fibres and acute axonal degeneration.

摘要

本文描述了一名56岁男性，患有与蕈样肉芽肿相关的急性感觉运动性多发性神经病。肌电图研究显示出肌肉失神经支配的弥漫性体征。皮肤活检标本显示真皮中有淋巴细胞浸润，由具有核膜深度内陷特征的蕈样细胞组成，表皮中有小的派特立尔微脓肿。腓肠神经活检显示神经内膜纤维化、有髓纤维数量减少以及急性轴突变性。