成人自闭症在不同年龄组和能力水平下的流行病学。

Epidemiology of autism in adults across age groups and ability levels.

机构信息

Traolach S. Brugha, MD(NUI) FRCPsych, Nicola Spiers, MSc PhD, Department of Health Sciences, University of Leicester, Leicester; John Bankart, MSc PhD, Department of Primary Care and Health Sciences, University of Keele, Stoke-on-Trent; Sally-Ann Cooper, MD FRCPsych, Institute of Health and Wellbeing, University of Glasgow, Gartnavel Royal Hospital, Glasgow; Sally McManus, MSc, NatCen Social Research, London; Fiona J. Scott, PhD Cpsychol, Jane Smith, MSc, Freya Tyrer, MSc, Department of Health Sciences, University of Leciester, Leciester, UK

出版信息

Br J Psychiatry. 2016 Dec;209(6):498-503. doi: 10.1192/bjp.bp.115.174649. Epub 2016 Jul 7.

DOI:10.1192/bjp.bp.115.174649

PMID:27388569

Abstract

BACKGROUND

The epidemiology of autism in adults has relied on untested projections using childhood research.

AIMS

To derive representative estimates of the prevalence of autism and key associations in adults of all ages and ability levels.

METHOD

Comparable clinical diagnostic assessments of 7274 Adult Psychiatric Morbidity Survey participants combined with a population case-register survey of 290 adults with intellectual disability.

RESULTS

The combined prevalence of autism in adults of all ages in England was 11/1000 (95% CI 3-19/1000). It was higher in those with moderate to profound intellectual disability (odds ratio (OR) = 63.5, 95% CI 27.4-147.2). Male gender was a strong predictor of autism only in those with no or mild intellectual disability (adjusted OR = 8.5, 95% CI 2.0-34.9; interaction with gender, P = 0.03).

CONCLUSIONS

Few adults with autism have intellectual disability; however, autism is more prevalent in this population. Autism measures may miss more women with autism.

摘要

背景

成人自闭症的流行病学研究一直依赖于使用儿童研究未经测试的预测。

目的

旨在得出所有年龄段和能力水平的成人自闭症患病率和主要关联的代表性估计值。

方法

将 7274 名成人精神疾病调查参与者的可比临床诊断评估与 290 名智力残疾成人的人群病例登记调查相结合。

结果

在英格兰，所有年龄段的成年自闭症患病率为 11/1000（95%CI 3-19/1000）。在中度至重度智力残疾者中更高（优势比（OR）=63.5，95%CI 27.4-147.2）。仅在无或轻度智力残疾者中，男性性别是自闭症的一个强烈预测因素（调整后的 OR =8.5，95%CI 2.0-34.9；与性别相互作用，P=0.03）。