Nassif André Thá, Nagano Thais Ayumi, Okayama Sulamita, Nassif Luís Sérgio, Branco Filho Alcides, Sampaio Neto José
Hopital Santa Casa de Misericórdia de Curitiba, Praça Rui Barbosa, 694 - Centro, Curitiba, PR, 80010-030, Brazil.
Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Obes Surg. 2017 Feb;27(2):394-398. doi: 10.1007/s11695-016-2284-z.
Nonalcoholic fatty liver disease incidence is related to the presence of obesity and insulin resistance. A treatment of this disease in patients with morbid obesity is bariatric surgery and its diagnosis is extremely important due to the possible progression to cirrhosis or hepatocellular carcinoma. The development of clinical-laboratorial analysis tools to this disease and its complications is necessary as the gold standard for its diagnosis is an invasive procedure. The objective of the study is to evaluate the use of BARD score in the selection of patients who should undergo liver biopsy during bariatric surgery.
It was a retrospective analysis of patients with hepatic disease who were biopsied between 2012 and 2013. Their clinical and laboratory data were analyzed by BARD score. The results of those who presented score >2 were compared to the rest.
Two hundred ninety-eight patients with hepatic disease were analyzed and among them 70.27 % had score >2. Of the 76 patients with score <1, 1 was diagnosed with liver fibrosis, determining a negative predictive value of 98.68 % for the test (p < 0.05).
The BARD score is still not ideal for the diagnosis of nonalcoholic fatty liver disease, hepatitis, and fibrosis, but it was proved to be effective in the detection of absence of liver fibrosis in a bariatric population.
非酒精性脂肪性肝病的发病率与肥胖和胰岛素抵抗的存在有关。对于病态肥胖患者,这种疾病的一种治疗方法是减肥手术,由于其可能进展为肝硬化或肝细胞癌,其诊断极为重要。由于该疾病及其并发症的诊断金标准是侵入性检查,因此开发针对该疾病及其并发症的临床实验室分析工具很有必要。本研究的目的是评估BARD评分在减肥手术中选择应接受肝活检患者方面的应用。
对2012年至2013年间接受活检的肝病患者进行回顾性分析。通过BARD评分分析他们的临床和实验室数据。将评分>2的患者结果与其余患者进行比较。
对298例肝病患者进行了分析,其中70.27%的患者评分>2。在76例评分<1的患者中,有1例被诊断为肝纤维化,该检测的阴性预测值为�8.68%(p<0.05)。
BARD评分在非酒精性脂肪性肝病、肝炎和肝纤维化的诊断方面仍不理想,但在减肥人群中检测无肝纤维化方面被证明是有效的。