韩国猪G8P[7]重配轮状病毒的全基因组特征分析
Whole genomic characterization of Korean porcine G8P[7] reassortant rotaviruses.
作者信息
Park Jun-Gyu, Park Sang-Ik, Woo Nam-Il, Kim Deok-Song, Seo Ja-Young, Alfajaro Mia Madel, Kim Ji-Yun, Soliman Mahmoud, Baek Yeong-Bin, Cho Eun-Hyo, Kwon Joseph, Choi Jong-Soon, Kang Mun-Il, Matthijnssens Jelle, Cho Kyoung-Oh
机构信息
Laboratory of Veterinary Pathology, College of Veterinary Medicine, Chonnam National University, Gwangju, 500-757, Republic of Korea.
Division of Life Science, Korea Basic Science Institute, 169-148 Gwahak-ro, Yuseong-gu, Daejeon, 305-806, Republic of Korea.
出版信息
Arch Virol. 2016 Oct;161(10):2835-41. doi: 10.1007/s00705-016-2945-1. Epub 2016 Jul 9.
This study analyzed eleven genomic segments of three Korean porcine G8P[7] group A rotavirus (RVA) strains. Phylogenetically, these strains contained two bovine-like and nine porcine-like genomic segments. Eight genes (VP1, VP2, VP6 and NSP1-NSP5) of strains 156-1 and 42-1 and seven genes (VP1, VP2, VP6 and NSP2-NSP5) of strain C-1 clustered closely with porcine and porcine-like animal strains and distantly from typical human Wa-like strains. The VP3-M2 genotype of these strains clustered closely with bovine-like strains, but distantly with typical human DS-1-like strains. These data indicate that multiple reassortments involving porcine and bovine RVA strains in Korea must have occurred.
本研究分析了三株韩国猪G8P[7] A组轮状病毒（RVA）毒株的11个基因组片段。在系统发育上，这些毒株包含两个牛样和九个猪样基因组片段。156-1和42-1毒株的八个基因（VP1、VP2、VP6和NSP1-NSP5）以及C-1毒株的七个基因（VP1、VP2、VP6和NSP2-NSP5）与猪和猪样动物毒株紧密聚类，与典型的人Wa样毒株距离较远。这些毒株的VP3-M2基因型与牛样毒株紧密聚类，但与典型的人DS-1样毒株距离较远。这些数据表明，韩国猪和牛RVA毒株之间肯定发生了多次重配。
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