Pavord Ian D, Hilvering Bart, Shrimanker Rahul
Department of Respiratory Medicine, University of Oxford, Old Road, Oxford, OX3 7LE, UK; Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, OX3 7FZ, UK.
Department of Respiratory Medicine, University of Oxford, Old Road, Oxford, OX3 7LE, UK; Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, OX3 7FZ, UK; Laboratory of Translational Immunology, Department of Respiratory Medicine, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Immunol Allergy Clin North Am. 2016 Aug;36(3):609-23. doi: 10.1016/j.iac.2016.04.001.
Asthma is a heterogeneous disease that can be classified into different clinical endotypes, depending on the type of airway inflammation, clinical severity, and response to treatment. This article focuses on the eosinophilic endotype of asthma, which is defined by the central role that eosinophils play in the pathophysiology of the condition. It is characterized by persistently elevated sputum and/or blood eosinophils and by a significant response to treatments that suppress eosinophilia. Eosinophil activity in the airway may be more important than their numbers and this needs to be investigated. Transcriplomic or Metabolomic signatures may also be useful to identify this endotype.
哮喘是一种异质性疾病，可根据气道炎症类型、临床严重程度和对治疗的反应分为不同的临床亚型。本文重点关注哮喘的嗜酸性粒细胞亚型，该亚型由嗜酸性粒细胞在疾病病理生理学中所起的核心作用定义。其特征是痰液和/或血液中的嗜酸性粒细胞持续升高，以及对抑制嗜酸性粒细胞增多的治疗有显著反应。气道中的嗜酸性粒细胞活性可能比其数量更重要，这需要进行研究。转录组学或代谢组学特征也可能有助于识别该亚型。
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