使用普鲁士蓝纳米颗粒对革兰氏阳性和革兰氏阴性强毒及抗生素耐药菌株进行980纳米驱动的光热消融。
A 980nm driven photothermal ablation of virulent and antibiotic resistant Gram-positive and Gram-negative bacteria strains using Prussian blue nanoparticles.
作者信息
Maaoui Houcem, Jijie Roxana, Pan Guo-Hui, Drider Djamel, Caly Delphine, Bouckaert Julie, Dumitrascu Nicoleta, Chtourou Radouane, Szunerits Sabine, Boukherroub Rabah
机构信息
Institut d'Electronique, de Microélectronique et de Nanotechnologie (IEMN, UMR CNRS 8520), Université Lille 1, Avenue Poincaré, BP 60069, 59652 Villeneuve d'Ascq, France; Département de Physique, Faculté des Sciences de Tunis, Université Tunis-El Manar, 2092, Tunisia.
Institut d'Electronique, de Microélectronique et de Nanotechnologie (IEMN, UMR CNRS 8520), Université Lille 1, Avenue Poincaré, BP 60069, 59652 Villeneuve d'Ascq, France; Iasi Plasma Advanced Research Center (IPARC), Faculty of Physics, Alexandru Ioan Cuza University of Iasi, Bd. Carol I No. 11, Iasi 700506, Romania.
出版信息
J Colloid Interface Sci. 2016 Oct 15;480:63-68. doi: 10.1016/j.jcis.2016.07.002. Epub 2016 Jul 2.
A 980nm laser-driven antimicrobial photothermal therapy using poly(vinylpyrrolidone) -coated Prussian Blue nanoparticles (PVP/PB NPs) is demonstrated. This approach allows an efficient eradication of a virulent strain of Gram-negative Escherichia coli (E. coli) associated with urinary tract infection as well as for the ablation of antibiotic resistant pathogens such as methicillin resistant Staphylococcus aureus (MRSA) and extended spectrum β-lactamase (ESBL) E. coli. Interestingly the 980nm irradiation exhibits minimal effect on mammalian cells up to a PVP/PB NPs concentration of 50μgmL(-1), while at this concentration bacteria are completely eradicated. This feature is certainly very promising for the selective targeting of bacteria over mammalian cells.
本文展示了一种使用聚乙烯吡咯烷酮包覆的普鲁士蓝纳米颗粒（PVP/PB NPs）的980nm激光驱动抗菌光热疗法。这种方法能够有效根除与尿路感染相关的革兰氏阴性大肠杆菌（E. coli）的强毒株，以及消融耐抗生素病原体，如耐甲氧西林金黄色葡萄球菌（MRSA）和超广谱β-内酰胺酶（ESBL）大肠杆菌。有趣的是，在PVP/PB NPs浓度高达50μgmL(-1)时，980nm照射对哺乳动物细胞的影响极小，而在此浓度下细菌被完全根除。这一特性对于在哺乳动物细胞上选择性靶向细菌而言无疑非常有前景。
Zotero 插件