Bagal Bhausaheb, Ramadwar Mukta, Khattry Navin
Department of Medical Oncology, ACTREC, Tata Memorial Center, Mumbai, India.
Department of Pathology, Tata Memorial Center, Mumbai, India.
Indian J Hematol Blood Transfus. 2016 Jun;32(Suppl 1):189-91. doi: 10.1007/s12288-014-0477-y. Epub 2014 Dec 4.
Graft versus host disease (GVHD) usually have involvement of classical target organs. Manifestations of Chronic GVHD (cGVHD) are much more protean than acute GVHD. NIH consensus criterion for cGVHD proposes different diagnostic and distinctive features of cGVHD. It acknowledges certain uncommon manifestations that can be attributed to cGVHD only when they are associated with more specific features. Patients rarely may develop such manifestations which are not diagnostic of cGVHD themselves. In the absence of more specific features of cGVHD, they may pose diagnostic challenge. Amongst the rare reported manifestations of cGVHD is serositis manifesting as pleural effusion, pericardial effusion or ascites. We report two patients developing ascites as an isolated manifestation of cGVHD.
移植物抗宿主病(GVHD)通常累及经典靶器官。慢性移植物抗宿主病(cGVHD)的表现比急性移植物抗宿主病更为多样。美国国立卫生研究院(NIH)关于cGVHD的共识标准提出了cGVHD不同的诊断和独特特征。它承认某些不常见的表现,只有当它们与更具体的特征相关时,才可能归因于cGVHD。患者很少会出现这些本身不能诊断为cGVHD的表现。在缺乏cGVHD更具体特征的情况下,它们可能带来诊断挑战。cGVHD罕见的报道表现之一是浆膜炎,表现为胸腔积液、心包积液或腹水。我们报告了两名患者,腹水是cGVHD的唯一表现。