兔子的十年（2005 - 2015年）
THE DECADE OF THE RABiT (2005-15).
作者信息
Garty G, Turner H C, Salerno A, Bertucci A, Zhang J, Chen Y, Dutta A, Sharma P, Bian D, Taveras M, Wang H, Bhatla A, Balajee A, Bigelow A W, Repin M, Lyulko O V, Simaan N, Yao Y L, Brenner D J
机构信息
Center for Radiological Research, Columbia University, VC11-230, 630 West 168th Street, New York, NY 10032, USA
Center for Radiological Research, Columbia University, VC11-230, 630 West 168th Street, New York, NY 10032, USA.
出版信息
Radiat Prot Dosimetry. 2016 Dec;172(1-3):201-206. doi: 10.1093/rpd/ncw172. Epub 2016 Jul 13.
The RABiT (Rapid Automated Biodosimetry Tool) is a dedicated Robotic platform for the automation of cytogenetics-based biodosimetry assays. The RABiT was developed to fulfill the critical requirement for triage following a mass radiological or nuclear event. Starting from well-characterized and accepted assays we developed a custom robotic platform to automate them. We present here a brief historical overview of the RABiT program at Columbia University from its inception in 2005 until the RABiT was dismantled at the end of 2015. The main focus of this paper is to demonstrate how the biological assays drove development of the custom robotic systems and in turn new advances in commercial robotic platforms inspired small modifications in the assays to allow replacing customized robotics with 'off the shelf' systems. Currently, a second-generation, RABiT II, system at Columbia University, consisting of a PerkinElmer cell::explorer, was programmed to perform the RABiT assays and is undergoing testing and optimization studies.
RABiT（快速自动生物剂量测定工具）是一个专门用于基于细胞遗传学的生物剂量测定分析自动化的机器人平台。RABiT的开发是为了满足大规模放射或核事件后进行分流的关键需求。我们从特征明确且被广泛接受的分析方法入手，开发了一个定制的机器人平台来实现这些分析的自动化。在此，我们简要回顾一下哥伦比亚大学RABiT项目从2005年启动到2015年底RABiT被拆除期间的历史概况。本文的主要重点是展示生物分析如何推动定制机器人系统的开发，反过来，商业机器人平台的新进展又如何促使对分析方法进行小的改进，以便能用“现成的”系统取代定制机器人。目前，哥伦比亚大学的第二代RABiT II系统由珀金埃尔默公司的cell::explorer组成，已编程用于执行RABiT分析，正在进行测试和优化研究。
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