Axon R Neal, Gebregziabher Mulugeta, Dismuke Clara E, Hunt Kelly J, Yeager Derik, Ana Elizabeth J Santa, Egede Leonard E
Charleston Health Equity and Rural Outreach Innovation Center, Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
Division of General Internal Medicine, Department of Medicine, The Medical University of South Carolina, Charleston, SC, USA.
J Gen Intern Med. 2016 Nov;31(11):1331-1337. doi: 10.1007/s11606-016-3786-z. Epub 2016 Jul 14.
Veterans with evidence of homelessness have high rates of mental health and substance abuse disorders, but chronic medical conditions such as diabetes are also prevalent.
We aimed to determine the impact of homelessness on glycemic control in patients with type 2 diabetes mellitus.
Longitudinal analysis of a retrospective cohort.
A national cohort of 1,263,906 Veterans with type 2 diabetes. Subjects with evidence of homelessness were identified using a combination of diagnostic and administrative codes.
Odds for poor glycemic control using hemoglobin A1C (HbA1C) cutoff values of 8 % and 9 %. Homeless defined as a score based on the number of indicator variables for homelessness within a veterans chart.
Veterans with evidence of homelessness had a significantly greater annual mean HbA1C ≥ 8 (32.6 % vs. 20.43 %) and HbA1C ≥ 9 (21.4 % vs. 9.9 %), tended to be younger (58 vs. 67 years), were more likely to be non-Hispanic black (39.1 %), divorced (43 %) or never married (34 %), to be urban dwelling (88.8 %), and to have comorbid substance abuse (46.7 %), depression (42.3 %), psychoses (39.7 %), liver disease (18.8 %), and fluid/electrolyte disorders (20.4 %), relative to non-homeless veterans (all p < 0.0001). Homelessness was modeled as an ordinal variable that scored the number of times a homelessness indicator was found in the Veterans medical record. We observed a significant interaction between homelessness and race/ethnicity on the odds of poor glycemic control. Homelessness, across all racial-ethnic groups, was associated with increased odds of uncontrolled diabetes at a cut-point of 8 % and 9 % for hemoglobin A1C ; however, the magnitude of the association was greater in non-Hispanic whites [8 %, OR 1.55 (1.47;1.63)] and Hispanics [8 %, OR 2.11 (1.78;2.51)] than in non-Hispanic blacks [8 %, OR 1.22 (1.15;1.28)].
Homelessness is a significant risk factor for uncontrolled diabetes in Veterans, especially among non-Hispanic white and Hispanic patients. While efforts to engage homeless patients in primary care services have had some success in recent years, these data suggest that broader efforts targeting management of diabetes and other chronic medical conditions remain warranted.
有证据表明无家可归的退伍军人心理健康问题和药物滥用障碍发生率很高,但糖尿病等慢性疾病也很普遍。
我们旨在确定无家可归对2型糖尿病患者血糖控制的影响。
对回顾性队列进行纵向分析。
全国1,263,906名患有2型糖尿病的退伍军人队列。通过诊断和管理代码相结合的方式识别有无家可归证据的研究对象。
使用血红蛋白A1C(HbA1C)临界值8%和9%时血糖控制不佳的几率。无家可归定义为根据退伍军人病历中无家可归指标变量的数量得出的分数。
有证据表明无家可归的退伍军人年平均HbA1C≥8%(32.6%对20.43%)和HbA1C≥9%(21.4%对9.9%)的比例显著更高,往往更年轻(58岁对67岁),更可能是非西班牙裔黑人(39.1%)、离婚(43%)或从未结婚(34%),居住在城市(88.8%),且有合并药物滥用(46.7%)、抑郁症(42.3%)、精神病(39.7%)、肝病(18.8%)和体液/电解质紊乱(20.4%),与无家可归的退伍军人相比(所有p<0.0001)。无家可归被建模为一个有序变量,根据在退伍军人医疗记录中发现无家可归指标的次数进行评分。我们观察到无家可归与种族/民族之间在血糖控制不佳几率上存在显著交互作用。在所有种族/民族群体中,无家可归与HbA1C临界值为8%和9%时糖尿病控制不佳的几率增加相关;然而,非西班牙裔白人[8%,比值比1.55(1.47;1.63)]和西班牙裔[8%,比值比2.11(1.78;2.51)]中的关联程度大于非西班牙裔黑人[8%,比值比1.22(1.15;1.28)]。
无家可归是退伍军人糖尿病控制不佳的一个重要危险因素,尤其是在非西班牙裔白人和西班牙裔患者中。虽然近年来让无家可归患者参与初级保健服务的努力取得了一些成功,但这些数据表明,针对糖尿病和其他慢性疾病管理的更广泛努力仍然是必要的。