Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Department of Nephrology and Division of Clinical Toxicology, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Linkou, Taiwan.
Sci Rep. 2016 Jul 19;6:29656. doi: 10.1038/srep29656.
A paucity of literature exists on risk factors for mortality in charcoal burning suicide. In this observational study, we analyzed the data of 126 patients with charcoal burning suicide that seen between 2002 and 2013. Patients were grouped according to status of renal damage as acute kidney injury (N = 49) or non-acute kidney injury (N = 77). It was found that patients with acute kidney injury suffered severer complications such as respiratory failure (P = 0.002), myocardial injury (P = 0.049), hepatic injury (P < 0.001), rhabdomyolysis (P = 0.045) and out-of-hospital cardiac arrest (P = 0.028) than patients without acute kidney injury. Moreover, patients with acute kidney injury suffered longer hospitalization duration (16.9 ± 18.3 versus 10.7 ± 10.9, P = 0.002) and had higher mortality rate (8.2% versus 0%, P = 0.011) than patients without injury. In a multivariate Cox regression model, it was demonstrated that serum creatinine level (P = 0.019) and heart rate (P = 0.022) were significant risk factors for mortality. Finally, Kaplan-Meier analysis revealed that patients with acute kidney injury suffered lower cumulative survival than without injury (P = 0.016). In summary, the overall mortality rate of charcoal burning suicide population was 3.2%, and acute kidney injury was a powerful predictor of mortality. Further studies are warranted.
关于烧炭自杀死亡风险因素的文献很少。在这项观察性研究中,我们分析了 2002 年至 2013 年间 126 例烧炭自杀患者的数据。根据肾损伤情况将患者分为急性肾损伤组(N=49)和非急性肾损伤组(N=77)。结果发现,急性肾损伤患者发生呼吸衰竭(P=0.002)、心肌损伤(P=0.049)、肝损伤(P<0.001)、横纹肌溶解(P=0.045)和院外心脏骤停(P=0.028)等严重并发症的比例高于非急性肾损伤患者。此外,急性肾损伤患者的住院时间更长(16.9±18.3 比 10.7±10.9,P=0.002),死亡率更高(8.2%比 0%,P=0.011)。多变量 Cox 回归模型显示,血清肌酐水平(P=0.019)和心率(P=0.022)是死亡的显著危险因素。最后,Kaplan-Meier 分析显示,急性肾损伤患者的累积生存率低于无损伤患者(P=0.016)。总之,烧炭自杀人群的总体死亡率为 3.2%,急性肾损伤是死亡的有力预测因素。需要进一步研究。