控制干细胞：对限制生殖系统中微环境-干细胞信号传导机制的新见解。
Keeping stem cells under control: New insights into the mechanisms that limit niche-stem cell signaling within the reproductive system.
作者信息
Inaba Mayu, Yamashita Yukiko M, Buszczak Michael
机构信息
Department of Cell and Developmental Biology Medical School, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan.
Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan.
出版信息
Mol Reprod Dev. 2016 Aug;83(8):675-83. doi: 10.1002/mrd.22682.
Adult stem cells reside in specialized microenvironments, called niches, that maintain stem cells in an undifferentiated and self-renewing state. Defining and understanding the mechanisms that restrict niche signaling exclusively to stem cells is crucial to determine how stem cells undergo self-renewal while their progeny, often located just one cell diameter away from the niche, differentiate. Despite extensive studies on the signaling pathways that operate within stem cells and their niches, how this segregation occurs remains elusive. Here we review recent progress on the characterization of niche-stem cell interactions, with a focus on emerging mechanisms that spatially restrict niche signaling. Mol. Reprod. Dev. 83: 675-683, 2016 © 2016 Wiley Periodicals, Inc.
成体干细胞存在于称为龛的特殊微环境中，这些微环境将干细胞维持在未分化和自我更新状态。定义并理解将龛信号专门限制于干细胞的机制，对于确定干细胞如何进行自我更新而其后代（通常距离龛仅一个细胞直径）却发生分化至关重要。尽管对干细胞及其龛内运作的信号通路进行了广泛研究，但这种分隔是如何发生的仍不清楚。在这里，我们综述了龛-干细胞相互作用特征的最新进展，重点关注在空间上限制龛信号的新出现机制。《分子生殖与发育》83: 675 - 683, 2016 © 2016威利期刊公司
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