迷迭香酸通过细胞外调节蛋白激酶1/2（Erk1/2）和蛋白激酶B（Akt）信号通路、自噬以及叉头框蛋白O3a（FoxO3a）保护饥饿诱导的人神经母细胞瘤细胞（SH-SY5Y）死亡。
Carnosic acid protects starvation-induced SH-SY5Y cell death through Erk1/2 and Akt pathways, autophagy, and FoxO3a.
作者信息
Shibata Sachi, Ishitobi Hiroyuki, Miyaki Shigeru, Kawaoka Tomohiro, Kayashima Tomoko, Matsubara Kiminori
机构信息
a Department of Human Life Science Education, Graduate School of Education , Hiroshima University , Hiroshima , Japan ;
b Department of Regenerative Medicine , Medical Center for Translational and Clinical Research, Hiroshima University Hospital , Hiroshima , Japan ;
出版信息
Int J Food Sci Nutr. 2016 Dec;67(8):977-82. doi: 10.1080/09637486.2016.1208734. Epub 2016 Jul 19.
Carnosic acid (CA) is recognized as a unique neuroprotective compound in the herb rosemary, since it induces expression of antioxidant enzymes including heme oxygenase-1 (HO-1), γ-glutamylcysteine synthase (γ-GCS), and glutathione S-transferase (GST) via activation of nuclear factor erythroid 2-related factor 2 (Nrf2), which is a nuclear transcription factor. In this study, we examined the cytoprotective effects of CA against starvation. We found that CA protected starvation-induced SH-SY5Y cell death by activating Akt and extracellular signal-regulated kinase 1/2 (Erk1/2). Interestingly, CA induced moderate autophagy and dephosphorylation of a transcriptional factor, the forkhead box protein O3a (FoxO3a). These effects of CA play an important role in cytoprotection.
迷迭香酸（CA）被认为是迷迭香叶中一种独特的神经保护化合物，因为它通过激活核转录因子核因子红细胞2相关因子2（Nrf2）来诱导包括血红素加氧酶-1（HO-1）、γ-谷氨酰半胱氨酸合成酶（γ-GCS）和谷胱甘肽S-转移酶（GST）在内的抗氧化酶的表达。在本研究中，我们检测了CA对饥饿的细胞保护作用。我们发现，CA通过激活Akt和细胞外信号调节激酶1/2（Erk1/2）来保护饥饿诱导的SH-SY5Y细胞死亡。有趣的是，CA诱导了适度的自噬和转录因子叉头框蛋白O3a（FoxO3a）的去磷酸化。CA的这些作用在细胞保护中发挥着重要作用。
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