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漏斗部腺瘤的放射外科治疗:对柄部剂量的影响

Radiosurgery for infundibulum adenoma: stalk dose implications.

作者信息

Sokolowski Jennifer D, Cohen-Inbar Or, Sheehan Jason P

机构信息

Department of Neurological Surgery, University of Virginia, PO Box 800212, Charlottesville, VA, 22908, USA.

Department of Neurosurgery, Rambam Health Care Center, Haifa Israel Molecular Immunology &Tumor Immunotherapy Laboratory, Technion Institute of Technology, Haifa, Israel.

出版信息

Acta Neurochir (Wien). 2016 Sep;158(9):1697-700. doi: 10.1007/s00701-016-2894-1. Epub 2016 Jul 19.

Abstract

Treating pituitary adenomas in the infundibulum with stereotactic radiosurgery (SRS), achieving tumor volume control while preserving pituitary endocrine function and visual function, is challenging. We present a case of a recurrent remnant infundibular lesion treated with Gamma Knife surgery (GKS). The mass was treated with microsurgical resection twice, and the residual stalk lesion was treated with single-session SRS employing a margin dose of 15 Gy to the infundibulum. Five years after GKS, tumor regression persists without visual dysfunction or hypopituitarism. Radiosurgical doses of 30 Gy to the pituitary stalk may be tolerated by patients while maintaining endocrine function.

摘要

采用立体定向放射外科(SRS)治疗漏斗部垂体腺瘤,在保留垂体内分泌功能和视觉功能的同时实现肿瘤体积控制具有挑战性。我们报告一例经伽玛刀手术(GKS)治疗的复发性漏斗部残留病变病例。该肿块接受了两次显微手术切除,残留的柄部病变采用单次SRS治疗,漏斗部边缘剂量为15 Gy。GKS治疗五年后,肿瘤持续消退,无视觉功能障碍或垂体功能减退。垂体柄接受30 Gy的放射外科剂量,患者在维持内分泌功能的同时可能可以耐受。

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