日本人群中与化疗引起的恶心和呕吐相关的多态性的基因型频率。
Genotype frequencies for polymorphisms related to chemotherapy-induced nausea and vomiting in a Japanese population.
作者信息
Goto Aya, Kotani Haruka, Miyazaki Masayuki, Yamada Kiyofumi, Ishikawa Kazuhiro, Shimoyama Yasuhiko, Niwa Toshimitsu, Hasegawa Yoshinori, Noda Yukihiro
机构信息
Division of Clinical Sciences and Neuropsychopharmacology, Faculty and Graduate School of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku Nagoya, 468-8503 Japan.
Division of Clinical Sciences and Neuropsychopharmacology, Faculty and Graduate School of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku Nagoya, 468-8503 Japan ; Department of Neuropsychopharmacology and Hospital Pharmacy, Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku Nagoya, 466-8550 Japan.
出版信息
J Pharm Health Care Sci. 2016 Jul 21;2:16. doi: 10.1186/s40780-016-0049-4. eCollection 2016.
BACKGROUND
Genotype frequencies for chemotherapy-induced nausea and vomiting (CINV)-related polymorphisms have not yet been reported for Japanese subjects.
METHODS
We analyzed 10 genotype frequencies for following polymorphisms associated with the development of CINV: serotonin 5-HT3 receptors (HTR3); neurokinin-1 receptors (Tachykinin-1 receptors, TACR1); dopamine D2 receptors (DRD2); and catechol-O-methyltransferase (COMT).
RESULTS
All polymorphisms were successfully genotyped in 200 Japanese subjects and were in Hardy-Weinberg equilibrium. Almost all genotype frequencies were similar to those in the HapMap database or in the previous reports, while frequencies for the Y192H polymorphism in TACR1 were different in Japanese subjects from those in a previous report.
CONCLUSIONS
The present study revealed genotype frequencies for polymorphisms, which were related to the appearance of CINV in Japanese subjects. Individual therapy based on genotype variations for each race is needed to allow cancer patients to undergo chemotherapy more safely and to understand etiology of CINV.
背景
日本人群中尚未报道化疗引起的恶心和呕吐（CINV）相关多态性的基因型频率。
方法
我们分析了与CINV发生相关的以下多态性的10种基因型频率：5-羟色胺5-HT3受体（HTR3）；神经激肽-1受体（速激肽-1受体，TACR1）；多巴胺D2受体（DRD2）；以及儿茶酚-O-甲基转移酶（COMT）。
结果
在200名日本受试者中成功对所有多态性进行了基因分型，且均处于哈迪-温伯格平衡状态。几乎所有基因型频率与HapMap数据库或先前报告中的频率相似，而TACR1中Y192H多态性在日本受试者中的频率与先前报告中的不同。
结论
本研究揭示了与日本受试者中CINV出现相关的多态性的基因型频率。需要根据每个种族的基因型变异进行个体化治疗，以使癌症患者更安全地接受化疗，并了解CINV的病因。
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