Passaretti S, Sorghi M, Colombo E, Mazzotti G, Tittobello A, Guslandi M
Gastroenterology Unit, University of Milan, Italy.
Int J Clin Pharmacol Ther Toxicol. 1989 Jan;27(1):47-50.
The effects of pinaverium bromide, a non-absorbable antispasmodic agent, administered locally, on sigmoid-rectal motility was investigated in 20 patients with irritable bowel syndrome. The influence of either pinaverium (10 subjects) or placebo (10 subjects) on a neostigmine-induced increase of sigmoid pressure was assessed and compared by means of computerized electromanometry. The drug was found to counteract significantly the motor effects of neostigmine, thus appearing to be an effective compound for the treatment of functional disorders of the colon.
对20例肠易激综合征患者研究了局部应用非吸收性解痉剂匹维溴铵对乙状结肠-直肠运动的影响。通过计算机化测压法评估并比较了匹维溴铵(10例受试者)或安慰剂(10例受试者)对新斯的明引起的乙状结肠压力升高的影响。发现该药物能显著对抗新斯的明的运动效应,因此似乎是治疗结肠功能紊乱的有效化合物。