Amlung Michael, Vedelago Lana, Acker John, Balodis Iris, MacKillop James
Peter Boris Centre for Addictions Research, McMaster University/St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.
Center for Integrated Healthcare, Syracuse VA Medical Center, Syracuse, NY, USA.
Addiction. 2017 Jan;112(1):51-62. doi: 10.1111/add.13535. Epub 2016 Sep 1.
To synthesize continuous associations between delayed reward discounting (DRD) and both addiction severity and quantity-frequency (QF); to examine moderators of these relationships; and to investigate publication bias.
Meta-analysis of published studies examining continuous associations between DRD and addictive behaviors. Published, peer-reviewed studies on addictive behaviors (alcohol, tobacco, cannabis, stimulants, opiates and gambling) were identified via PubMed, MEDLINE and PsycInfo. Studies were restricted to DRD measures of monetary gains. Random-effects meta-analysis was conducted using Pearson's r as the effect size. Publication bias was evaluated using fail-safe N, Begg-Mazumdar and Egger's tests, meta-regression of publication year and effect size and imputation of missing studies.
The primary meta-analysis revealed a small magnitude effect size that was highly significant (r = 0.14, P < 10 ). Significantly larger effect sizes were observed for studies examining severity compared with QF (P = 0.01), but not between the type of addictive behavior (P = 0.30) or DRD assessment (P = 0.90). Indices of publication bias suggested a modest impact of unpublished findings.
Delayed reward discounting is associated robustly with continuous measures of addiction severity and quantity-frequency. This relation is generally robust across type of addictive behavior and delayed reward discounting assessment modality.
综合延迟奖励折扣(DRD)与成瘾严重程度及数量频率(QF)之间的连续关联;检验这些关系的调节因素;并调查发表偏倚。
对已发表研究进行荟萃分析,这些研究考察了DRD与成瘾行为之间的连续关联。通过PubMed、MEDLINE和PsycInfo检索已发表的、经过同行评审的关于成瘾行为(酒精、烟草、大麻、兴奋剂、阿片类药物和赌博)的研究。研究仅限于金钱收益的DRD测量。采用Pearson相关系数r作为效应量进行随机效应荟萃分析。使用失效安全数N、Begg-Mazumdar检验和Egger检验、发表年份和效应量的元回归以及缺失研究的插补来评估发表偏倚。
主要荟萃分析显示效应量较小但高度显著(r = 0.14,P < 0.001)。与QF相比,考察严重程度的研究观察到的效应量显著更大(P = 0.01),但在成瘾行为类型(P = 0.30)或DRD评估(P = 0.90)之间没有差异。发表偏倚指标表明未发表研究有一定影响。
延迟奖励折扣与成瘾严重程度和数量频率的连续测量密切相关。这种关系在成瘾行为类型和延迟奖励折扣评估方式上总体上较为稳健。