TCR信号通路对胸腺细胞发育过程中SATB1的调控。
Regulation of SATB1 during thymocyte development by TCR signaling.
作者信息
Gottimukkala Kamalvishnu P, Jangid Rahul, Patta Indumathi, Sultana Dil Afroz, Sharma Archna, Misra-Sen Jyoti, Galande Sanjeev
机构信息
Indian Institute of Science Education and Research, Pune 411008, India.
National Institute on Aging, NIH and School of Medicine Immunology Graduate Program, Johns Hopkins University, Baltimore, MD, USA.
出版信息
Mol Immunol. 2016 Sep;77:34-43. doi: 10.1016/j.molimm.2016.07.005. Epub 2016 Jul 25.
T lymphocyte development and differentiation is a multi-step process that begins in the thymus and completed in the periphery. Sequential development of thymocytes is dependent on T cell receptor (TCR) signaling and an array of transcription factors. In this study we show that special AT-rich binding protein 1 (SATB1), a T lineage-enriched chromatin organizer and regulator, is induced in response to TCR signaling during early thymocyte development. SATB1 expression profile coincides with T lineage commitment and upregulation of SATB1 correlates with positive selection of thymocytes. CD4 thymocytes exhibit a characteristic bimodal expression pattern that corresponds to immature and mature CD4 thymocytes. We also demonstrate that GATA3, the key transcriptional regulator of αβ T cells positively regulates SATB1 expression in thymocytes suggesting an important role for SATB1 during T cell development.
T淋巴细胞的发育和分化是一个多步骤过程，始于胸腺并在外周完成。胸腺细胞的顺序发育依赖于T细胞受体（TCR）信号传导和一系列转录因子。在本研究中，我们表明特殊富含AT的结合蛋白1（SATB1），一种T谱系富集的染色质组织者和调节因子，在早期胸腺细胞发育过程中响应TCR信号而被诱导。SATB1表达谱与T谱系定型相吻合，SATB1的上调与胸腺细胞的阳性选择相关。CD4胸腺细胞表现出一种特征性的双峰表达模式，对应于未成熟和成熟的CD4胸腺细胞。我们还证明，αβ T细胞的关键转录调节因子GATA3在胸腺细胞中正向调节SATB1表达，提示SATB1在T细胞发育过程中起重要作用。
Zotero 插件