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信号素4D和丛状蛋白B1的联合表达可预测结直肠癌的疾病复发。

The combined expression of Semaphorin4D and PlexinB1 predicts disease recurrence in colorectal cancer.

作者信息

Ikeya Tetsuro, Maeda Kiyoshi, Nagahara Hisashi, Shibutani Masatsune, Iseki Yasuhito, Hirakawa Kosei

机构信息

Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan.

出版信息

BMC Cancer. 2016 Jul 25;16:525. doi: 10.1186/s12885-016-2577-6.

DOI:10.1186/s12885-016-2577-6
PMID:27456345
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4960918/
Abstract

BACKGROUND

Binding to Sema4D and PlexinB1 induce angiogenesis and invasive growth in colorectal cancer (CRC). The expression of Semaphorin4D (Sema4D) and PlexinB1 has been shown to be related to the prognosis of patients with various malignancies. However, the correlation between the expression of Sema4D and PlexinB1 and the relapse-free survival in patients with colorectal cancer remains controversial.

METHODS

The study population included patients who underwent surgery for colorectal cancer (n = 226). The expression of Sema4D and PlexinB1 were analyzed by immunohistochemistry in tissue of stage I, II, and III colon cancers.

RESULTS

The immunohistochemical staining of colorectal cancer tissue specimens revealed that 95 (42 %) and 105 (46.4 %) of the specimens were positive for Sema4D and PlexinB1. The expression of Sema4D and PlexinB1 respectively were both found to be significantly related to stage, depth of tumor invasion, lymph node metastasis, lymphatic invasion, and venous invasion, respectively. Sixty-three patients (27.9 %) expressed both Sema4D and PlexinB1. The positive expression of both Sema4D and PlexinB1 was found to be an independent risk factor for a worse survival (HR 1.079, CI 1.013-2.868; P = 0.044).

CONCLUSION

The combination of Sema4D and PlexinB1 protein detected by immunohistochemistry was therefore useful for predicting disease recurrence in CRC patients.

摘要

背景

与Sema4D和PlexinB1结合可诱导结直肠癌（CRC）的血管生成和侵袭性生长。已表明Semaphorin4D（Sema4D）和PlexinB1的表达与各种恶性肿瘤患者的预后相关。然而，Sema4D和PlexinB1的表达与结直肠癌患者无复发生存率之间的相关性仍存在争议。

方法

研究人群包括接受结直肠癌手术的患者（n = 226）。通过免疫组织化学分析I、II和III期结肠癌组织中Sema4D和PlexinB1的表达。

结果

结直肠癌组织标本的免疫组织化学染色显示，95份（42%）和105份（46.4%）标本的Sema4D和PlexinB1呈阳性。发现Sema4D和PlexinB1的表达分别与分期、肿瘤浸润深度、淋巴结转移、淋巴管浸润和静脉浸润显著相关。63例患者（27.9%）同时表达Sema4D和PlexinB1。发现Sema4D和PlexinB1均呈阳性表达是生存较差的独立危险因素（HR 1.079，CI 1.013 - 2.868；P = 0.044）。

结论

因此，免疫组织化学检测到的Sema4D和PlexinB1蛋白组合可用于预测CRC患者的疾病复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73d1/4960918/96f1033a71bd/12885_2016_2577_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73d1/4960918/db6cca2b4d55/12885_2016_2577_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73d1/4960918/ec1a306100a4/12885_2016_2577_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73d1/4960918/46624f5f98ab/12885_2016_2577_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73d1/4960918/96f1033a71bd/12885_2016_2577_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73d1/4960918/db6cca2b4d55/12885_2016_2577_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73d1/4960918/ec1a306100a4/12885_2016_2577_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73d1/4960918/46624f5f98ab/12885_2016_2577_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73d1/4960918/96f1033a71bd/12885_2016_2577_Fig4_HTML.jpg

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