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2%聚多卡醇超声引导下大隐静脉泡沫硬化疗法——一年随访结果

Ultrasound-guided foam sclerotherapy of great saphenous vein with 2% polidocanol - one-year follow-up results.

作者信息

Kurnicki Jacek, Osęka Marcin, Tworus Robert, Gałązka Zbigniew

机构信息

Department of General and Endocrine Surgery, Medical University of Warsaw, Warsaw, Poland.

出版信息

Wideochir Inne Tech Maloinwazyjne. 2016;11(2):67-75. doi: 10.5114/wiitm.2016.60579. Epub 2016 Jun 14.

Abstract

INTRODUCTION

Ultrasound-guided foam sclerotherapy (UGFS) of varicose veins is a useful treatment option. It is a relatively safe method in the case of limited, small varicose veins. In theory, a justified concern could be raised that the injection of an active drug into the large superficial venous vessels may potentially cause life-threatening consequences.

AIM

To assess the safety and efficacy of UGFS using a 2% solution of polidocanol (Aethoxysklerol 2%) in the case of great saphenous vein incompetence.

MATERIAL AND METHODS

Fifty-two patients with great saphenous vein incompetence underwent ultrasound-guided foam sclerotherapy. The efficacy criterion was the elimination of reflux measured ultrasonographically and withdrawal or decrease of complaints: 1 week, and 1, 3, 6 and 12 months after the treatment. Complications of sclerotherapy were reported during follow-up.

RESULTS

Decrease or withdrawal of complaints of chronic venous insufficiency was reported in 96% of cases (50 patients). Disappearance or decrease of varicose veins was noted in all patients (100%). During examination after 12 months, full success of ultrasound was achieved in 38 (73%) cases, and 11 (21%) patients presented a partial desired effect according to the consensus from Tegernsee. Persistence of reflux longer than 1 s in the treated great saphenous vein was reported in 3 (6%) cases. Serious complications, such as deep vein thrombosis, pulmonary embolism, dyspnea, anaphylaxis, or neurological abnormalities, were not recorded.

CONCLUSIONS

Ultrasound-guided foam sclerotherapy of incompetent great saphenous vein and varicosities with 2% polidocanol was found to be an effective and safe method of treatment during 1 year of observation. However, longer observation is necessary.

摘要

引言

超声引导下泡沫硬化疗法(UGFS)治疗静脉曲张是一种有效的治疗选择。对于局限性、小范围的静脉曲张,这是一种相对安全的方法。理论上,将活性药物注入大的浅静脉血管可能会引发危及生命的后果,这一担忧是合理的。

目的

评估在大隐静脉功能不全的情况下,使用2%聚多卡醇溶液(Aethoxysklerol 2%)进行超声引导下泡沫硬化疗法的安全性和有效性。

材料与方法

52例大隐静脉功能不全患者接受了超声引导下泡沫硬化疗法。疗效标准为通过超声检查消除反流以及在治疗后1周、1、3、6和12个月时症状减轻或消失。在随访期间报告硬化疗法的并发症。

结果

96%(50例)的患者报告慢性静脉功能不全的症状减轻或消失。所有患者(100%)的静脉曲张均消失或减轻。在12个月后的检查中,38例(73%)患者超声检查完全成功,11例(21%)患者根据特格恩湖共识呈现部分预期效果。3例(6%)患者的治疗大隐静脉中反流持续时间超过1秒。未记录到严重并发症,如深静脉血栓形成、肺栓塞、呼吸困难、过敏反应或神经异常。

结论

在1年的观察期内,发现使用2%聚多卡醇对功能不全的大隐静脉和静脉曲张进行超声引导下泡沫硬化疗法是一种有效且安全的治疗方法。然而,需要更长时间的观察。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce52/4945613/f3156b280105/WIITM-11-27757-g001.jpg

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