头颈部癌患者葡萄糖摄取与代谢的磁共振成像
Magnetic Resonance Imaging of Glucose Uptake and Metabolism in Patients with Head and Neck Cancer.
作者信息
Wang Jihong, Weygand Joseph, Hwang Ken-Pin, Mohamed Abdallah S R, Ding Yao, Fuller Clifton D, Lai Stephen Y, Frank Steven J, Zhou Jinyuan
机构信息
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
出版信息
Sci Rep. 2016 Jul 27;6:30618. doi: 10.1038/srep30618.
Imaging metabolic dysfunction, a hallmark of solid tumors, usually requires radioactive tracers. Chemical exchange saturation transfer (CEST) imaging can potentially detect and visualize glucose uptake and metabolism, without the need for radioisotopes. Here, we tested the feasibility of using glucose CEST (glucoCEST) to image unlabeled glucose uptake in head and neck cancer by using a clinical 3T magnetic resonance imaging (MRI) scanner. The average CEST contrast between tumors and normal tissue in 17 patients was 7.58% (P = 0.006) in the 3-4 ppm offset frequency range and 5.06% (P = 0.02) in 1-5 ppm range. In a subgroup of eight patients, glucoCEST signal enhancement was higher in tumors than in normal muscle (4.98% vs. 1.28%, P < 0.021). We conclude that glucoCEST images of head and neck cancer can be obtained with a clinical 3T MRI scanner.
成像代谢功能障碍是实体瘤的一个标志，通常需要放射性示踪剂。化学交换饱和转移（CEST）成像有可能检测并可视化葡萄糖摄取和代谢，而无需放射性同位素。在此，我们通过使用临床3T磁共振成像（MRI）扫描仪，测试了利用葡萄糖CEST（glucoCEST）对头颈部癌中未标记葡萄糖摄取进行成像的可行性。17例患者肿瘤与正常组织之间的平均CEST对比度在3 - 4 ppm偏移频率范围内为7.58%（P = 0.006），在1 - 5 ppm范围内为5.06%（P = 0.02）。在8例患者的亚组中，肿瘤中的glucoCEST信号增强高于正常肌肉（4.98%对1.28%，P < 0.021）。我们得出结论，使用临床3T MRI扫描仪可以获得头颈部癌的glucoCEST图像。
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