精神分裂症患者自杀的危险因素：一项聚焦于脑脊液中高香草酸和5-羟吲哚乙酸水平的队列研究
Risk factors for suicide among patients with schizophrenia: a cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid.
作者信息
Neider Daniel, Lindström Leif H, Bodén Robert
机构信息
Department of Neuroscience, Psychiatry, Uppsala University, Uppsala University Hospital, Uppsala, Sweden.
出版信息
Neuropsychiatr Dis Treat. 2016 Jul 11;12:1711-4. doi: 10.2147/NDT.S107178. eCollection 2016.
Abstract
BACKGROUND
The objective of this study was to investigate the association between 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) in cerebrospinal fluid (CSF), bullying, and later suicide among patients with schizophrenia.
METHODS
Ninety-nine patients with schizophrenia were included. Correlations of clinical factors, 5-HIAA and HVA, and later suicide were investigated.
RESULTS
Twelve patients committed suicide (12%) during a 28-year follow-up period. Later suicide was correlated to bullying in childhood (P=0.02) and a lower quotient of HVA/5-HIAA in CSF (P<0.05).
CONCLUSION
Suicide in schizophrenia is related to childhood exposedness and CSF neurotransmitter levels.
摘要
背景
本研究的目的是调查精神分裂症患者脑脊液（CSF）中5-羟吲哚乙酸（5-HIAA）和高香草酸（HVA）、欺凌行为与后期自杀之间的关联。
方法
纳入99例精神分裂症患者。研究临床因素、5-HIAA和HVA与后期自杀之间的相关性。
结果
在28年的随访期内，12例患者自杀（12%）。后期自杀与童年期受欺凌（P=0.02）以及脑脊液中HVA/5-HIAA比值较低（P<0.05）相关。
结论
精神分裂症患者的自杀与童年期受欺凌经历和脑脊液神经递质水平有关。
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