芬太尼透皮贴剂在下颌第三磨牙手术后疼痛控制中的疗效：一项初步研究。
Efficacy of fentanyl transdermal patch in pain control after lower third molar surgery: A preliminary study.
作者信息
Todorovic V-S, Vasovic M, Andric M, Todorovic L, Kokovic V
机构信息
School of Dental Medicine, University of Belgrade, Serbia,
出版信息
Med Oral Patol Oral Cir Bucal. 2016 Sep 1;21(5):e621-5. doi: 10.4317/medoral.21161.
BACKGROUND
Surgical removal of impacted lower third molars is a common oral surgical procedure, generally followed by moderate to severe postoperative pain. Transdermal drug delivery as a concept offers interesting possibilities for postoperative pain control. The aim of this study was to evaluate the efficacy of transdermal system with fentanyl in relieving pain following impacted lower third molar surgery.
MATERIAL AND METHODS
Seventeen patients with bilateral impacted lower third molars were included in this preliminary study. For postoperative pain control, patients randomly received a fentanyl patch plus placebo tablet after the first operation and regular (placebo) patch and an analgesic, after the second operation. Analgesia was evaluated during first 24 hours postoperatively according to patients' reports about time of first pain appearance and additional analgesic consumption. Pain severity was rated using a 10 cm long visual analogue scale (VAS).
RESULTS
Intensity of postoperative pain and postoperative analgesic consumption were significantly lower after the Fentanyl Transdermal System (FTS) was applied (p<0.05). Duration of postoperative analgesia was significantly higher with FTS when compared to control treatment (p<0.05).
CONCLUSIONS
Based on the results of this preliminary study, transdermal system with fentanyl significantly reduced postoperative pain after third molar surgery.
背景
外科拔除阻生下颌第三磨牙是一种常见的口腔外科手术，术后通常会出现中度至重度疼痛。透皮给药作为一种理念为术后疼痛控制提供了有趣的可能性。本研究的目的是评估含芬太尼的透皮系统在缓解阻生下颌第三磨牙手术后疼痛方面的疗效。
材料与方法
本初步研究纳入了17例双侧阻生下颌第三磨牙患者。为控制术后疼痛，患者在第一次手术后随机接受一片芬太尼贴片加一片安慰剂片剂，在第二次手术后接受常规（安慰剂）贴片和一种镇痛药。根据患者关于首次疼痛出现时间和额外镇痛药消耗的报告，在术后24小时内评估镇痛效果。使用10厘米长的视觉模拟量表（VAS）对疼痛严重程度进行评分。
结果
应用芬太尼透皮系统（FTS）后，术后疼痛强度和术后镇痛药消耗量显著降低（p<0.05）。与对照治疗相比，FTS的术后镇痛持续时间显著更长（p<0.05）。
结论
基于本初步研究的结果，含芬太尼的透皮系统显著减轻了第三磨牙手术后的疼痛。
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