用于选择性杀死癌细胞的半乳糖修饰的光响应性水凝胶前体

Galactose-decorated light-responsive hydrogelator precursors for selectively killing cancer cells.

作者信息

Ji Wei, Liu Guofeng, Wang Fang, Zhu Zhu, Feng Chuanliang

机构信息

State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, 200240, Shanghai, China.

Department of Nephrology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, 227 South Chongqing Road, 200011, Shanghai, China.

出版信息

Chem Commun (Camb). 2016 Oct 18;52(85):12574-12577. doi: 10.1039/c6cc05707a.

DOI:10.1039/c6cc05707a

PMID:27477036

Abstract

A multi-functional gelator precursor with high photosensitivity is rationally designed, which can not only selectively target hepatocellular carcinoma (HCC) cells, but also form intracellular self-assembly triggered by light and subsequently inducing cell death. The study develops a methodology to design biological targets of supramolecular self-assembly under external stimuli for cancer research.

摘要

合理设计了一种具有高光敏性的多功能凝胶剂前体，它不仅可以选择性地靶向肝癌（HCC）细胞，还能在光触发下在细胞内形成自组装，随后诱导细胞死亡。该研究开发了一种在外部刺激下设计用于癌症研究的超分子自组装生物靶点的方法。