Elkhatib Ahmad H, Soldatova Liuba, Carrau Ricardo L, Hachem Ralph Abi, Ditzel Leo, Campbell Raewyn, Prevedello Daniel M, Prevedello Luciano, Filho Leo F S Ditzel, Campbell Raewyn G
Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Ohio, U.S.A.
College of Medicine, The Ohio State University, Columbus, Ohio, U.S.A.
Laryngoscope. 2017 Feb;127(2):321-324. doi: 10.1002/lary.26194. Epub 2016 Aug 2.
The purpose of this study is to demonstrate the potential contribution of positron emission tomography (PET)/computed tomography (CT) to help differentiate olfactory neuroblastoma (ONB) from sinonasal undifferentiated carcinoma (SNUC).
Following approval by the institutional review board at the Wexner Medical Center at the Ohio State University, Columbus, Ohio, a pilot study with retrospective review of patients with biopsy-proven diagnosis of ONB s and SNUC s was conducted. Staging PET/CT scans were reviewed to document the maximum standardized uptake value (SUVmax). A statistical comparison of SUVmax was performed.
We identified 13 patients (7 with ONBs and 6 with SNUCs) with mean age 60.2 years who had undergone staging F-18 fluorodeoxyglucose ( F-FDG) PET/CT of the primary tumor at the time of their diagnosis. Mean SUVmax was found to be five-fold higher in SNUC patients (35.63, range 10.8-77.9) than in ONB patients (7.24, range 4.6-10.7) (P ≤ 0.00169).
Maximum standardized uptake value of F-FDG PET/CT can be used to initially discriminate between ONB and SNUC. This finding may prove helpful to guide diagnostic and treatment planning when the histopathologic diagnosis is inconclusive.
本研究旨在证明正电子发射断层扫描（PET）/计算机断层扫描（CT）在帮助区分嗅神经母细胞瘤（ONB）和鼻窦未分化癌（SNUC）方面的潜在作用。
经俄亥俄州哥伦布市俄亥俄州立大学韦克斯纳医学中心机构审查委员会批准，开展了一项回顾性试点研究，纳入经活检确诊为ONB和SNUC的患者。对分期PET/CT扫描进行回顾，记录最大标准化摄取值（SUVmax）。对SUVmax进行统计学比较。
我们确定了13例患者（7例ONB和6例SNUC），平均年龄60.2岁，在诊断时均接受了原发肿瘤的F-18氟脱氧葡萄糖（F-FDG）PET/CT分期检查。发现SNUC患者的平均SUVmax（35.63，范围10.8 - 77.9）比ONB患者（7.24，范围4.6 - 10.7）高五倍（P≤0.00169）。
F-FDG PET/CT的最大标准化摄取值可用于初步区分ONB和SNUC。当组织病理学诊断不明确时，这一发现可能有助于指导诊断和治疗计划。
4。《喉镜》，2016年127卷：321 - 324页，2017年。
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