来自库曼豚草（Ambrosia cumanensis Kunth.）的新型倍半萜内酯
New sesquiterpene lactones from Ambrosia cumanensis Kunth.
作者信息
Jimenez-Usuga Nora Del Socorro, Malafronte Nicola, Cotugno Roberta, De Leo Marinella, Osorio Edison, De Tommasi Nunziatina
机构信息
Grupo de Investigacion en Sustancias Bioactivas, Facultad de Ciencias Farmaceuticas y Alimentarias, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellin, Colombia.
Dipartimento di Farmacia, Università di Salerno, Via Giovanni Paolo II, 84084 Fisciano, Salerno, Italy.
出版信息
Fitoterapia. 2016 Sep;113:170-4. doi: 10.1016/j.fitote.2016.07.019. Epub 2016 Aug 2.
Eleven sesquiterpene lactones, including three new natural products (1-3), were isolated from the n-butanolic extract of Ambrosia cumanensis Kunth. aerial parts. The structure of all isolated compounds was elucidated by 1D- and 2D-NMR, and MS analyses. All compounds were tested for their antiproliferative activity on HeLa, Jurkat, and U937 cell lines. Compound 3, 2,3-dehydropsilostachyn C, showed cytotoxic activity with different potency in all cell lines. By means of flow cytometric studies, compound 3 was demonstrated to induce in Jurkat cells a G2/M cell cycle block, while in U937 elicited both cytostatic and cytotoxic responses.
从豚草（Ambrosia cumanensis Kunth.）地上部分的正丁醇提取物中分离出11种倍半萜内酯，其中包括3种新的天然产物（1-3）。通过一维和二维核磁共振以及质谱分析确定了所有分离化合物的结构。测试了所有化合物对HeLa、Jurkat和U937细胞系的抗增殖活性。化合物3（2,3-脱氢水苏碱C）在所有细胞系中均表现出不同程度的细胞毒性活性。通过流式细胞术研究表明，化合物3可诱导Jurkat细胞发生G2/M期细胞周期阻滞，而在U937细胞中则引发了细胞生长抑制和细胞毒性反应。
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