利用心率变异性鉴别特发性震颤与早期震颤为主型帕金森病。

Heart rate variability to differentiate essential tremor from early-stage tremor-dominant Parkinson's disease.

作者信息

Yoon Jung Han, Kim Min Seung, Lee Sun Min, Kim Hyun Jae, Hong Ji Man

机构信息

Department of Neurology, Ajou University School of Medicine, Suwon, South Korea.

出版信息

J Neurol Sci. 2016 Sep 15;368:55-8. doi: 10.1016/j.jns.2016.06.059. Epub 2016 Jun 29.

DOI:10.1016/j.jns.2016.06.059

PMID:27538602

Abstract

BACKGROUND

Essential tremor (ET) and Parkinson's disease (PD) are the most common movement disorders in the elderly, but it is difficult to differentiate ET from early-stage tremor-dominant Parkinson's disease (TDPD).

METHODS

We investigated heart rate variability (HRV) in 23 patients with ET, 27 patients with TDPD, and 23 healthy controls. HRV was determined using the RR intervals of a 5-min electrocardiogram recording. Measurements of beat-to-beat RR variability, including time domains [(standard deviation of the normal-to-normal RR interval (SDNN), and the root mean square difference of successive RR intervals (RMSSD)] and frequency domains [low-frequency (LF) and high-frequency (HF) components and total spectral power (TP)], were assessed retrospectively.x

RESULTS

In the TDPD group, SDNN, LF, HF, and TP were significantly lower than those in the ET group. In a receiver operating characteristic area under the curve (AUC) analysis, LF was the best potential diagnostic marker (AUC=0.87).

CONCLUSION

Non-invasive and routine electrocardiography may be helpful in differentiating ET from TDPD during the early disease stage.

摘要

背景

特发性震颤（ET）和帕金森病（PD）是老年人中最常见的运动障碍，但早期难以将ET与震颤为主型帕金森病（TDPD）相鉴别。

方法

我们对23例ET患者、27例TDPD患者和23名健康对照者进行了心率变异性（HRV）研究。使用5分钟心电图记录的RR间期来测定HRV。回顾性评估逐搏RR变异性测量，包括时域[正常RR间期标准差（SDNN）和连续RR间期均方根差（RMSSD）]和频域[低频（LF）和高频（HF）成分及总谱功率（TP）]。