心脏中转录因子乙酰化的机制及其后果
Mechanisms of transcription factor acetylation and consequences in hearts.
作者信息
Thiagarajan Devi, Vedantham Srinivasan, Ananthakrishnan Radha, Schmidt Ann Marie, Ramasamy Ravichandran
机构信息
Diabetes Research Program, Division of Endocrinology, Department of Medicine, NYU Langone Medical Center, NY, New York 10016, United States.
Department of Biotechnology, SASTRA University, Thanjavur, India.
出版信息
Biochim Biophys Acta. 2016 Dec;1862(12):2221-2231. doi: 10.1016/j.bbadis.2016.08.011. Epub 2016 Aug 17.
Abstract
Acetylation of proteins as a post-translational modification is gaining rapid acceptance as a cellular control mechanism on par with other protein modification mechanisms such as phosphorylation and ubiquitination. Through genetic manipulations and evolving proteomic technologies, identification and consequences of transcription factor acetylation is beginning to emerge. In this review, we summarize the field and discuss newly unfolding mechanisms and consequences of transcription factor acetylation in normal and stressed hearts. This article is part of a Special Issue entitled: The role of post-translational protein modifications on heart and vascular metabolism edited by Jason R.B. Dyck & Jan F.C. Glatz.
摘要
蛋白质乙酰化作为一种翻译后修饰，正迅速被视为一种与磷酸化和泛素化等其他蛋白质修饰机制相当的细胞调控机制。通过基因操作和不断发展的蛋白质组学技术，转录因子乙酰化的鉴定及其影响正逐渐显现。在这篇综述中，我们总结了该领域的研究，并讨论了正常和应激心脏中转录因子乙酰化新出现的机制及其影响。本文是名为《翻译后蛋白质修饰对心脏和血管代谢的作用》特刊的一部分，由杰森·R·B·戴克和扬·F·C·格拉茨编辑。
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