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使用双相磷酸钙和水凝胶聚乙二醇覆盖膜进行上颌窦底提升:组织学和组织形态计量学评估

Maxillary Sinus Floor Augmentation Using Biphasic Calcium Phosphate and a Hydrogel Polyethylene Glycol Covering Membrane: An Histological and Histomorphometric Evaluation.

作者信息

Ohayon Laurent, Taschieri Silvio, Corbella Stefano, Del Fabbro Massimo

机构信息

*Private Practice, Saint Maur des Fosses, France. †Department of Biomedical, Surgical and Dental Sciences, Research Center in Oral Health, Università degli Studi di Milano, Milan, Italy. ‡IRCCS Istituto Ortopedico Galeazzi, Dental Clinic, Milan, Italy. §Department of Biomedical, Surgical and Dental Sciences, Research Center in Oral Implantology, Università degli Studi di Milano, Milan, Italy.

出版信息

Implant Dent. 2016 Oct;25(5):599-605. doi: 10.1097/ID.0000000000000435.

Abstract

PURPOSE

Maxillary sinus floor augmentation with a lateral approach is usually performed using a bone substitute covered with standard collagen or a synthetic barrier membrane to prevent soft tissue ingrowth within the bone graft. The purpose of this case series was to evaluate a polyethylene glycol (PEG) membrane with a hydrogel consistency, used to protect the lateral sinus anstrotomy, by analyzing the histological quality and histomorphometric quantity of newly formed bone (NB) in a maxillary sinus graft using biphasic calcium phosphate (BCP).

MATERIALS AND METHODS

Fifteen sinuses were grafted from 12 patients. Six months after the maxillary sinus floor augmentation, bone biopsies were harvested from 7 patients during the implant placement second-step surgery.

RESULTS

The histomorphometric evaluation of the 7 grafted sinuses showed mean values of 27.4 ± 4.6% for NB, 26.9 ± 5.4% for remaining BCP particles, and 45.7 ± 6.0% for connective tissue/bone marrow. No implant failure was observed in the 14- to 45-month follow-up period after maxillary sinus floor augmentation procedure and in the 8- to 39-month follow-up period after implant loading.

CONCLUSION

The use of a hydrogel PEG membrane to protect BCP proved to be a valuable grafting procedure to enhance the vital bone formation in the maxillary sinus floor augmentation procedure.

摘要

目的

上颌窦底外侧入路增高术通常采用覆盖标准胶原蛋白或合成屏障膜的骨替代物来防止软组织长入骨移植材料内。本病例系列的目的是通过分析使用双相磷酸钙(BCP)进行上颌窦移植时新形成骨(NB)的组织学质量和组织形态计量学数量,评估具有水凝胶稠度的聚乙二醇(PEG)膜用于保护外侧鼻窦开窗术的效果。

材料与方法

从12例患者身上获取15个鼻窦进行移植。在上颌窦底增高术后6个月,在7例患者植入种植体的二期手术过程中采集骨活检样本。

结果

对7个移植鼻窦的组织形态计量学评估显示,NB的平均值为27.4±4.6%,剩余BCP颗粒的平均值为26.9±5.4%,结缔组织/骨髓的平均值为45.7±6.0%。在上颌窦底增高术后14至45个月的随访期以及种植体加载后8至39个月的随访期内,未观察到种植体失败情况。

结论

使用水凝胶PEG膜保护BCP被证明是一种有价值的移植方法,可在上颌窦底增高术中促进活性骨形成。

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