铑(III)催化的芳基与乙烯基苯并恶唑烷酮的区域和立体选择性 C-H 烯丙基化反应。
Rhodium(III)-Catalyzed Regio- and Stereoselective C-H Allylation of Arenes with Vinyl Benzoxazinanones.
机构信息
Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.
出版信息
Org Lett. 2016 Sep 2;18(17):4392-5. doi: 10.1021/acs.orglett.6b02146. Epub 2016 Aug 24.
PMID:27554130
Abstract
Vinyl benzoxazinanone was applied as an electrophilic allylating reagent for a series of arenes under redox-neutral Rh(III) catalysis. This reaction occurs in high efficiency under mild conditions to afford allylarenes bearing a sulfonamide functionality in exclusively E-selectivity. This allylation system combines C-H activation of arenes and scission of an unstrained six-membered ring.
摘要
乙烯基苯并恶唑烷酮作为亲电烯丙基化试剂，在氧化还原中性 Rh(III)催化下应用于一系列芳烃。该反应在温和条件下以高效率进行，可得到在 E-选择性中仅含有磺酰胺官能团的烯丙基芳烃。该烯丙基化体系结合了芳烃的 C-H 活化和无张力六元环的断裂。
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