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斑马鱼:用于生育力研究的多功能动物模型。

Zebrafish: A Versatile Animal Model for Fertility Research.

作者信息

Hoo Jing Ying, Kumari Yatinesh, Shaikh Mohd Farooq, Hue Seow Mun, Goh Bey Hing

机构信息

Biomedical Research Laboratory, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia; School of Science, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia; Sunway College, Jalan Universiti, Bandar Sunway, 46150 Petaling Jaya, Selangor Darul Ehsan, Malaysia.

Neuropharmacology Research Laboratory, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia.

出版信息

Biomed Res Int. 2016;2016:9732780. doi: 10.1155/2016/9732780. Epub 2016 Jul 31.

Abstract

The utilization of zebrafish in biomedical research is very common in the research world nowadays. Today, it has emerged as a favored vertebrate organism for the research in science of reproduction. There is a significant growth in amount numbers of scientific literature pertaining to research discoveries in reproductive sciences in zebrafish. It has implied the importance of zebrafish in this particular field of research. In essence, the current available literature has covered from the very specific brain region or neurons of zebrafish, which are responsible for reproductive regulation, until the gonadal level of the animal. The discoveries and findings have proven that this small animal is sharing a very close/similar reproductive system with mammals. More interestingly, the behavioral characteristics and along with the establishment of animal courtship behavior categorization in zebrafish have laid an even stronger foundation and firmer reason on the suitability of zebrafish utilization in research of reproductive sciences. In view of the immense importance of this small animal for the development of reproductive sciences, this review aimed at compiling and describing the proximate close similarity of reproductive regulation on zebrafish and human along with factors contributing to the infertility, showing its versatility and its potential usage for fertility research.

摘要

如今,斑马鱼在生物医学研究中的应用在科研领域非常普遍。如今,它已成为生殖科学研究中备受青睐的脊椎动物。关于斑马鱼生殖科学研究发现的科学文献数量大幅增长。这暗示了斑马鱼在这一特定研究领域的重要性。从本质上讲,当前的现有文献涵盖了斑马鱼非常特定的负责生殖调节的脑区或神经元,直至动物的性腺水平。这些发现证明,这种小动物与哺乳动物拥有非常相近/相似的生殖系统。更有趣的是,斑马鱼的行为特征以及动物求偶行为分类的建立,为斑马鱼在生殖科学研究中的应用奠定了更坚实的基础和更有力的理由。鉴于这种小动物对生殖科学发展的巨大重要性,本综述旨在汇编和描述斑马鱼与人类生殖调节的近乎相似之处以及导致不孕的因素,展示其多功能性及其在生育研究中的潜在用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e35/4983327/f993e304c902/BMRI2016-9732780.001.jpg

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