聚酮化合物中含氧和含氮杂环的生物合成。
Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides.
作者信息
Hemmerling Franziska, Hahn Frank
机构信息
Institut für Organische Chemie and Zentrum für Biomolekulare Wirkstoffe, Gottfried Wilhelm Leibniz Universität Hannover, Schneiderberg 38, 30167 Hannover, Germany; Fakultät für Biologie, Chemie und Geowissenschaften, Universität Bayreuth, Universitätsstraße 30, 95440 Bayreuth, Germany.
出版信息
Beilstein J Org Chem. 2016 Jul 20;12:1512-50. doi: 10.3762/bjoc.12.148. eCollection 2016.
This review highlights the biosynthesis of heterocycles in polyketide natural products with a focus on oxygen and nitrogen-containing heterocycles with ring sizes between 3 and 6 atoms. Heterocycles are abundant structural elements of natural products from all classes and they often contribute significantly to their biological activity. Progress in recent years has led to a much better understanding of their biosynthesis. In this context, plenty of novel enzymology has been discovered, suggesting that these pathways are an attractive target for future studies.
本综述重点介绍了聚酮类天然产物中杂环的生物合成，着重关注含有3至6个原子环的含氧和含氮杂环。杂环是各类天然产物中丰富的结构元素，它们通常对其生物活性有显著贡献。近年来的进展使人们对其生物合成有了更好的理解。在这方面，已发现大量新颖的酶学，这表明这些途径是未来研究的一个有吸引力的目标。
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