细胞信号转导与癌症中的甲羟戊酸途径的相互作用。
The interplay between cell signalling and the mevalonate pathway in cancer.
机构信息
Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada M5G 1L7.
Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5G 1L7.
出版信息
Nat Rev Cancer. 2016 Nov;16(11):718-731. doi: 10.1038/nrc.2016.76. Epub 2016 Aug 26.
The mevalonate (MVA) pathway is an essential metabolic pathway that uses acetyl-CoA to produce sterols and isoprenoids that are integral to tumour growth and progression. In recent years, many oncogenic signalling pathways have been shown to increase the activity and/or the expression of MVA pathway enzymes. This Review summarizes recent advances and discusses unique opportunities for immediately targeting this metabolic vulnerability in cancer with agents that have been approved for other therapeutic uses, such as the statin family of drugs, to improve outcomes for cancer patients.
甲羟戊酸（MVA）途径是一种重要的代谢途径，它利用乙酰辅酶 A 来产生甾醇和异戊二烯，这些物质是肿瘤生长和进展的关键。近年来，许多致癌信号通路已被证明可以增加 MVA 途径酶的活性和/或表达。本文总结了最近的进展，并讨论了利用已经批准用于其他治疗用途的药物（如他汀类药物）立即针对癌症这种代谢脆弱性的独特机会，以改善癌症患者的治疗效果。
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