基于皂苷的纳米乳化改善了AML-12细胞中维生素A和E的抗氧化特性。
Saponin-Based Nanoemulsification Improves the Antioxidant Properties of Vitamin A and E in AML-12 Cells.
作者信息
Choudhry Qaisra Naheed, Kim Mi Jeong, Kim Tae Gyun, Pan Jeong Hoon, Kim Jun Ho, Park Sung Jin, Lee Jin Hyup, Kim Young Jun
机构信息
Department of Food and Biotechnology, Korea University, 2511 Sejongro, Jochiwon, Sejong 339-700, Korea.
出版信息
Int J Mol Sci. 2016 Aug 26;17(9):1406. doi: 10.3390/ijms17091406.
Abstract
Our work aimed to investigate the protective effects of saponin-based nanoemulsions of vitamin A and E against oxidative stress-induced cellular damage in AML-12 cells. Saponin nanoemulsions of vitamin A (SAN) and vitamin E (SEN) were prepared by high-pressure homogenization and characterized in terms of size, zeta potential, and polydispersity index. SEN and SAN protect AML-12 cells against oxidative stress-induced cellular damage more efficiently via scavenging reactive oxygen species (ROS), and reducing DNA damage, protein carbonylation, and lipid peroxidation. These results provide valuable information for the development of nanoemulsion-based delivery systems that would improve the antioxidant properties of vitamin A and E.
摘要
我们的工作旨在研究基于皂苷的维生素A和E纳米乳剂对急性髓系白血病12（AML-12）细胞中氧化应激诱导的细胞损伤的保护作用。通过高压均质法制备了维生素A皂苷纳米乳剂（SAN）和维生素E皂苷纳米乳剂（SEN），并对其粒径、ζ电位和多分散指数进行了表征。SEN和SAN通过清除活性氧（ROS），减少DNA损伤、蛋白质羰基化和脂质过氧化，更有效地保护AML-12细胞免受氧化应激诱导的细胞损伤。这些结果为开发基于纳米乳剂的递送系统提供了有价值的信息，该系统将改善维生素A和E的抗氧化性能。
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