在猪模型中使用CorMatrix进行实验性主动脉瓣叶延长
Experimental Aortic Valve Cusp Extension with CorMatrix in a Porcine Model.
作者信息
Mosala Nezhad Zahra, Poncelet Alain, Fervaille Caroline, de Kerchove Laurent, Gianello Pierre
机构信息
Department of Cardiovascular and Thoracic Surgery, Université Catholique de Louvain, Cliniques Universitaire Saint Luc, Brussels, Belgium.
Laboratory of Anatomy Pathology, Université Catholique de Louvain, Mont-Godinne Hospital-CHU, Mont-Godinne, Belgium.
出版信息
Thorac Cardiovasc Surg. 2017 Apr;65(3):206-210. doi: 10.1055/s-0036-1586756. Epub 2016 Sep 1.
We tested the feasibility of using porcine small intestinal submucosal extracellular matrix (CorMatrix) for aortic valve (AV) repair in porcine model examining its resorption and remodeling potential. The non-coronary cusp was replaced with CorMatrix in four animals for 120 days. Valve function was assessed by echocardiography. Explants were examined by histology, immunohistochemistry, and collagen assessment. CorMatrix was almost totally replaced with tissue resembling the native cusp with a partial two-layer architecture. However, function was lost due to thickening and calcification. Tested in high-pressure AV position in a pig model, CorMatrix degrades and remodels, but also loses function.
我们在猪模型中测试了使用猪小肠黏膜下层细胞外基质（CorMatrix）进行主动脉瓣（AV）修复的可行性，研究其吸收和重塑潜力。在四只动物中用CorMatrix替换非冠状动脉瓣叶120天。通过超声心动图评估瓣膜功能。通过组织学、免疫组织化学和胶原蛋白评估对植入物进行检查。CorMatrix几乎完全被类似于天然瓣叶的组织所取代，具有部分两层结构。然而，由于增厚和钙化，功能丧失。在猪模型的高压AV位置进行测试时，CorMatrix会降解和重塑，但也会失去功能。
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