奥氮平作为帕利哌酮所致 Pisa 综合征的一种可能替代选择：一例病例报告。
Olanzapine as a possible replacement choice for paliperidone-induced Pisa syndrome: a case report.
作者信息
Tsou Chang-Chih, Huang San-Yuan
机构信息
Resident, Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Attending Physician, Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, and; Professor, Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan
出版信息
Australas Psychiatry. 2016 Dec;24(6):545-547. doi: 10.1177/1039856216665285. Epub 2016 Sep 2.
OBJECTIVE
The aim of this paper is to present a case of paliperidone-induced Pisa syndrome and provide treatment experience.
METHOD
The case report is combined with a review of the literature.
RESULTS
A 37-year-old man had been diagnosed with paranoid-type schizophrenia for about 10 years. He received three-month treatment of paliperidone extended release (ER) at 6 mg per day, but showed a progressively Pisa-like physical position. We initially added an anticholinergic drug, but saw no improvement. The paliperidone ER was replaced by olanzapine at 10 mg per day, and the Pisa-like symptom improved after 1 month of the drug replacement.
CONCLUSIONS
We propose olanzapine as a possible replacement choice for patients with paliperidone-related Pisa syndrome.
目的
本文旨在介绍1例帕利哌酮所致比萨综合征病例并提供治疗经验。
方法
该病例报告结合文献复习。
结果
一名37岁男性被诊断为偏执型精神分裂症约10年。他接受了为期3个月的帕利哌酮缓释片治疗，每日6毫克，但逐渐出现类似比萨斜塔样的身体姿势。我们最初加用了一种抗胆碱能药物，但未见改善。将帕利哌酮缓释片换为每日10毫克的奥氮平，换药1个月后，类似比萨斜塔样症状改善。
结论
我们建议奥氮平可作为帕利哌酮相关比萨综合征患者的一种可能的替代选择。
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