利用2-脱氧-2-[F]氟-D-葡萄糖正电子发射断层扫描和计算机断层扫描对进展性HIV相关结核病进行特征分析。
Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[F]fluoro-D-glucose positron emission and computed tomography.
作者信息
Esmail Hanif, Lai Rachel P, Lesosky Maia, Wilkinson Katalin A, Graham Christine M, Coussens Anna K, Oni Tolu, Warwick James M, Said-Hartley Qonita, Koegelenberg Coenraad F, Walzl Gerhard, Flynn JoAnne L, Young Douglas B, Barry Iii Clifton E, O'Garra Anne, Wilkinson Robert J
机构信息
Department of Medicine, Imperial College London, London, UK.
Clinical Infectious Disease Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
出版信息
Nat Med. 2016 Oct;22(10):1090-1093. doi: 10.1038/nm.4161. Epub 2016 Sep 5.
Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral-therapy-naive, HIV-1-infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalities suggestive of subclinical, active disease who were substantially more likely to progress to clinical disease. Our findings challenge the conventional two-state paradigm and may aid future identification of biomarkers that are predictive of progression.
结核病传统上分为潜伏感染状态和活动性疾病状态。我们对35名无症状、未接受过抗逆转录病毒治疗、感染了HIV-1且患有潜伏性结核病的成年人进行了正电子发射断层扫描和计算机断层扫描相结合的检查，发现其中10人肺部有异常，提示存在亚临床活动性疾病，这些人发展为临床疾病的可能性要大得多。我们的研究结果挑战了传统的两状态范式，可能有助于未来识别预测疾病进展的生物标志物。
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