Donkor Jimmy, Armenian Patil, Hartman Isaac N, Vohra Rais
Department of Emergency Medicine, University of California, San Francisco-Fresno, Fresno, California.
Department of Emergency Medicine, University of California, San Francisco-Fresno, Fresno, California; California Poison Control System, Fresno-Madera Division, Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, Madera, California.
J Emerg Med. 2016 Oct;51(4):394-400. doi: 10.1016/j.jemermed.2016.05.050. Epub 2016 Aug 29.
As decontamination trends have evolved, gastric lavage (GL) has become a rare procedure. The current information regarding use, outcomes, and complications of GL could help refine indications for this invasive procedure.
We sought to determine case type, location, and complications of GL cases reported to a statewide poison control system.
This is a retrospective review of the California Poison Control System (CPCS) records from 2009 to 2012. Specific substances ingested, results and complications of GL, referring hospital ZIP codes, and outcomes were examined.
Nine hundred twenty-three patients who underwent GL were included in the final analysis, ranging in age from 9 months to 88 years. There were 381 single and 540 multiple substance ingestions, with pill fragment return in 27%. Five hundred thirty-six GLs were performed with CPCS recommendation, while 387 were performed without. Complications were reported for 20 cases. There were 5 deaths, all after multiple ingestions. Among survivors, 37% were released from the emergency department, 13% were admitted to hospital wards, and 48% were admitted to intensive care units. The most commonly ingested substances were nontricyclic antidepressant psychotropics (n = 313), benzodiazepines (n = 233), acetaminophen (n = 191), nonsteroidal anti-inflammatory drugs (n = 107), diphenhydramine (n = 70), tricyclic antidepressants (n = 45), aspirin (n = 45), lithium (n = 36), and antifreeze (n = 10). The geographic distribution was clustered near regions of high population density, with a few exceptions.
Toxic agents for which GL was performed reflected a broad spectrum of potential hazards, some of which are not life-threatening or have effective treatments. Continuing emergency physician and poison center staff education is required to assist in patient selection.
随着净化趋势的演变,洗胃术(GL)已成为一种罕见的操作。目前有关洗胃术的使用、结果及并发症的信息有助于完善这一侵入性操作的适应证。
我们试图确定向全州毒物控制系统报告的洗胃术病例的病例类型、地点及并发症。
这是一项对2009年至2012年加利福尼亚毒物控制系统(CPCS)记录的回顾性研究。检查了摄入的具体物质、洗胃术的结果及并发症、转诊医院的邮政编码及结局。
最终分析纳入了923例行洗胃术的患者,年龄从9个月至88岁不等。有381例单次摄入和540例多种物质摄入,27%的患者有药丸碎片排出。536例洗胃术是根据CPCS的建议进行的,而387例是在无建议的情况下进行的。报告了20例并发症。有5例死亡,均为多种物质摄入后。在幸存者中,37%从急诊科出院,13%入住医院病房,48%入住重症监护病房。最常摄入的物质为非三环类抗抑郁精神药物(n = 313)、苯二氮䓬类(n = 233)、对乙酰氨基酚(n = 191)、非甾体抗炎药(n = 107)、苯海拉明(n = 70)、三环类抗抑郁药(n = 45)、阿司匹林(n = 45)、锂(n = 36)及防冻液(n = 10)。地理分布在人口密度高的地区附近聚集,有少数例外。
进行洗胃术的有毒物质反映了广泛的潜在危害,其中一些并不危及生命或有有效的治疗方法。需要持续对急诊医生和毒物中心工作人员进行教育,以协助进行患者选择。