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[肢体和躯干壁软组织肉瘤的手术治疗]

[Surgery for soft-tissue sarcomas of the limbs and trunk wall].

作者信息

Stoeckle E, Michot A, Henriques B, Sargos P, Honoré C, Ferron G, Meeus P, Babre F, Bonvalot S

机构信息

Service de chirurgie, institut Bergonié, 229, cours de l'Argonne, 33076 Bordeaux cedex, France.

Service de chirurgie, institut Bergonié, 229, cours de l'Argonne, 33076 Bordeaux cedex, France.

出版信息

Cancer Radiother. 2016 Oct;20(6-7):657-65. doi: 10.1016/j.canrad.2016.07.068. Epub 2016 Sep 3.

Abstract

Soft-tissue sarcoma of the limbs or the trunk wall determine a heterogeneous group of tumours that tends to receive a more individualized approach. The surgeon in charge with soft-tissue sarcoma has to be familiar with these tumours in order to deliver an adequate treatment. Most important is the initial diagnostic procedure, comprising imaging with MRI, a core needle biopsy, and in France, referral to a centre of expertise within the clinical network NETSARC. Prior to surgery, a multidisciplinary conference determines its moment and the extent of surgical resection within the frame of a multidisciplinary approach, and also plans reconstructive surgery, when needed. A standardized operative report summarizes items necessary to describe the resection quality (i.e. tumour seen, tumour infiltrated?). In multidisciplinary staff meetings, they are compared to margins measured by the pathologist on the operative specimen. Hence, resection quality is determined collegially and defined by resection type R (R0, R1, R2) as a qualitative result. The quality of resection directly determines the 5-year risk of local recurrence, estimated between 10 and 20% in specialized centres, with the objective to attain 10%. Early rehabilitation favours better functional outcome. The surgeon's experience with soft-tissue sarcoma, as part of a multidisciplinary treatment, is key in achieving the best adequacy between oncological resection and favourable functional outcome. In France, a specific university course for soft-tissue sarcoma will be set-up.

摘要

肢体或躯干壁的软组织肉瘤是一组异质性肿瘤,往往需要更个体化的治疗方法。负责软组织肉瘤治疗的外科医生必须熟悉这些肿瘤,以便提供充分的治疗。最重要的是初始诊断程序,包括磁共振成像(MRI)、粗针活检,在法国还包括转诊至临床网络NETSARC内的专业中心。手术前,多学科会议确定手术时机和多学科治疗框架内的手术切除范围,并在需要时规划重建手术。一份标准化的手术报告总结了描述切除质量(即是否可见肿瘤、肿瘤是否浸润?)所需的项目。在多学科人员会议上,将这些项目与病理学家在手术标本上测量的切缘进行比较。因此,切除质量由多学科共同确定,并根据切除类型R(R0、R1、R2)作为定性结果进行定义。切除质量直接决定局部复发的5年风险,在专业中心估计为10%至20%,目标是达到10%。早期康复有利于获得更好的功能结果。作为多学科治疗的一部分,外科医生对软组织肉瘤的经验是在肿瘤切除和良好功能结果之间实现最佳平衡的关键。在法国,将开设一门关于软组织肉瘤的特定大学课程。

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